June 2019. Volume 15. Number 2

Thrombopenia in premature infants: looking for the ideal threshold to transfuse

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Curley A, Stanworth SJ, Willoughby K, Fustolo‑Gunnink SF, Venkatesh V, Hudson C, et al. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med. 2019;380:242-51.

Reviewers: Aparicio Sánchez JL1, Rivas Fernández MÁ2.
1Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
2Hospital Universitario General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: José Luis Aparicio Sánchez. Email: japaricio1970@gmail.com
Reception date: 22/04/2019
Acceptance date: 29/04/2019
Publication date: 08/05/2019

Abstract

Authors’ conclusions: in thrombocytopenic preterm neonates, refraining from transfusing platelets prophylactically until their platelet counts reach levels below 25 000/mm3, decreases their risk of mortality or of serious bleeding.

Reviewers’ commentary: his unprecedented RCT – of excellent methodological quality – concludes that in clinical practice the threshold of prophylactic transfusions of platelets for preterm infants under 34 weeks, (currently fixed empirically at 50 000/mm3), should be reduced to figures below 25 000/mm3.

How to cite this article

Aparicio Sánchez JL, Rivas-Fernández MA. Trombopenia en prematuros: buscando el umbral ideal para transfundir. Evid Pediatr. 2019;15:18.

AVC | Critically appraised articles

Curley A, Stanworth SJ, Willoughby K, Fustolo‑Gunnink SF, Venkatesh V, Hudson C, et al. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med. 2019;380:242-51.

Reviewers: Aparicio Sánchez JL1, Rivas Fernández MÁ2.
1Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
2Hospital Universitario General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: José Luis Aparicio Sánchez. Email: japaricio1970@gmail.com
Reception date: 22/04/2019
Acceptance date: 29/04/2019
Publication date: 08/05/2019

How to cite this article

Aparicio Sánchez JL, Rivas-Fernández MA. Trombopenia en prematuros: buscando el umbral ideal para transfundir. Evid Pediatr. 2019;15:18.


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