Authors’ conclusions: the efficacy of single probiotic supplements is limited, compared to combined use of probiotics. To achieve optimal effect on premature infant health, combined use of prebiotic and probiotic, especially Lactobacillus or Bifidobacterium, is recommended.
Reviewers’ commentary: this study shows that the use of synbiotics in premature infants seems to be beneficial, especially the combined use of Lactobacillus spp. and Bifidobacterium spp. However, these results should be taken with caution before translating them into clinical practice, as the most appropriate dose and time of treatment and efficacy in the most immature infants cannot yet be cdetermined.