March 2025. Volume 21. Number 1

Combined or alternating therapy is more effective against fever, but is this the question?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

De la Cruz-Mena JE, Veroniki AA, Acosta-Reyes J, Estupiñán-Bohorquez A, Ibarra JA, Pana MC, et al. Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis. Pediatrics. 2024;154:e2023065390.

Reviewers: Esparza Olcina MJ1, Pérez Solís D2.
1Pediatra de Atención Primaria. Madrid. España.
2Servicio de Pediatría. Hospital Universitario San Agustín. Avilés. Asturias. España.
Correspondence: M.ª Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 11/02/2025
Acceptance date: 28/02/2025
Publication date: 12/03/2025

Abstract

Authors´ conclusions: dual may be superior to single therapy for treating fever in children and getting children afebrile at 4 and 6 hours. High dose ibuprofen was somewhat superior to acetaminophen at 4 hours, but not at 6 hours.

Reviewers´ commentary: alternating, and especially combined treatment, can produce the impression that fever suppression is of critical relevance, when the objective should be treating discomfort. It could also be a source of incorrect dosing. For these reasons, combined or alternating antipyretic treatment, though probably more effective, it proves unnecessary for failing to demonstrate their clinical utility.

How to cite this article

Esparza Olcina MJ, Pérez Solís, D. Combinar o alternar antitérmicos es más eficaz contra la fiebre, pero ¿es esa la cuestión? Evid Pediatr. 2025;21:9.

AVC | Critically appraised articles

De la Cruz-Mena JE, Veroniki AA, Acosta-Reyes J, Estupiñán-Bohorquez A, Ibarra JA, Pana MC, et al. Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis. Pediatrics. 2024;154:e2023065390.

Reviewers: Esparza Olcina MJ1, Pérez Solís D2.
1Pediatra de Atención Primaria. Madrid. España.
2Servicio de Pediatría. Hospital Universitario San Agustín. Avilés. Asturias. España.
Correspondence: M.ª Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 11/02/2025
Acceptance date: 28/02/2025
Publication date: 12/03/2025

How to cite this article

Esparza Olcina MJ, Pérez Solís, D. Combinar o alternar antitérmicos es más eficaz contra la fiebre, pero ¿es esa la cuestión? Evid Pediatr. 2025;21:9.


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