December 2008. Volume 4. Number 4

The programs for the prevention of perinatal invasive group B streptococcal disease are effective in reducing early neonatal mortality, but do not alter mortality at later age

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008;299:2056-65
Reviewers: Balaguer Santamaría A1, González de Dios J2.
1H General Catalunya. Sant Cugat del Vallés. Barcelona. España.
2Departamento de Pediatrí­a. Hospital General Universitario de Alicante. España.
Correspondence: Albert Balaguer Santamaría. Email: balaguer.albert@gmail.com
Reception date: 25/07/2008
Acceptance date: 28/07/2008
Publication date: 01/12/2008

Abstract

Authors' conclusions: there is a decline in the U.S. incidence of invasive disease by group B streptococcal disease (GBS) between birth and 6 days of life in 2003-2005 with respect to 1999-2000. However, there was no change in the incidence of late neonatal disease and an increase of invasive disease by GBS was registered in adults during the study period.

Reviewers' comantary: prevention of invasive disease by GBS based on intrapartum antibiotics, with its advantages and disadvantages, seems to have reached its limit. Therefore research for a pentavalent vaccine should be a public health priority.

How to cite this article

Balaguer A, González de Dios J. Los programas de prevención de la enfermedad invasiva perinatal por estreptococo del grupo B son eficaces para disminuir la mortalidad neonatal precoz, pero no modifican la mortalidad en edades posteriores. Evid Pediatr. 2008;4:72.

AVC | Critically appraised articles

Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008;299:2056-65
Reviewers: Balaguer Santamaría A1, González de Dios J2.
1H General Catalunya. Sant Cugat del Vallés. Barcelona. España.
2Departamento de Pediatrí­a. Hospital General Universitario de Alicante. España.
Correspondence: Albert Balaguer Santamaría. Email: balaguer.albert@gmail.com
Reception date: 25/07/2008
Acceptance date: 28/07/2008
Publication date: 01/12/2008

How to cite this article

Balaguer A, González de Dios J. Los programas de prevención de la enfermedad invasiva perinatal por estreptococo del grupo B son eficaces para disminuir la mortalidad neonatal precoz, pero no modifican la mortalidad en edades posteriores. Evid Pediatr. 2008;4:72.

References

  1. Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease: revised guidelines from CDC. MMWR Recomm Rep. 2002; 51(R-11):1-22.
  2. Carbonell-Estrany X, Figueras-Aloy J, Salcedo-Abizanda S, de la Rosa-Fraile M; Castrillo Study Group. Probable early-onset group B streptococcal neonatal sepsis: a serious clinical condition related to intrauterine infection. Arch Dis Child Fetal Neonatal Ed. 2008;93:F85-9.
  3. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Engl J Med. 2002;347:240-7.
  4. Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342:15-20.
01/12/2008

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