March 2009. Volume 5. Number 1

Montelukast is not effective in reducing the length of hospitalization in infants admitted for acute bronchiolitis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Amirav I, Luder AS, Kruger N, Borovitch Y, Babai I, Miron D, et al. A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis. Pediatrics. 2008;122:e1249-55
Reviewer: Buñuel Álvarez JC1.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 03/01/2009
Acceptance date: 08/01/2009
Publication date: 10/01/2009

Abstract

Authors' conclusions: montelukast was not effective in reducing the length of hospitalization in infants admitted for a first episode of acute bronchiolitis.

Reviewers' comantary: it is a clinical trial that, despite some limitations in the analysis of the results (lack of multivariate analysis of variables to correct imbalances between groups), offers good quality evidence about the absence of effectiveness of montelukast in reducing the length of hospitalization in children with a first episode of acute bronchiolitis.

How to cite this article

Buñuel Álvarez JC. Montelukast no es eficaz para disminuir la duración del ingreso hospitalario en lactantes ingresados por bronquiolitis aguda. Evid Pediatr. 2009;5:6.

AVC | Critically appraised articles

Amirav I, Luder AS, Kruger N, Borovitch Y, Babai I, Miron D, et al. A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis. Pediatrics. 2008;122:e1249-55
Reviewer: Buñuel Álvarez JC1.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 03/01/2009
Acceptance date: 08/01/2009
Publication date: 10/01/2009

How to cite this article

Buñuel Álvarez JC. Montelukast no es eficaz para disminuir la duración del ingreso hospitalario en lactantes ingresados por bronquiolitis aguda. Evid Pediatr. 2009;5:6.

References

  1. Wainwright C, Altamirano L, Cheney M, Cheney J, Barber S, Price D, et al. A multicenter, randomized, double-blind, controlled trial of nebulized epinephrine in infants with acute bronchiolitis. N Engl J Med. 2003;349(1):27-35.
  2. Sánchez Etxaniz J, Benito Fernández Javier, Mintegi Raso Santiago. Bronquiolitis aguda: ¿por qué no se aplica lo que se publica? Barreras en la transmisión del conocimiento Evid Pediatr. 2007;3:88.
  3. Bisgaard H; Study Group on Montelukast and Respiratory Syncytial Virus. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med. 2003;167:379-83.
  4. Bisgaard H, Flores-Nunez A, Goh A, Azimi P, Halkas A, Malice MP, et al. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children. Am J Respir Crit Care Med. 2008 Oct 15;178:854-60.
  5. Buñuel Álvarez JC. Actualmente no hay pruebas que apoyen la eficacia de montelukast en el tratamiento de la bronquiolitis aguda leve en atención primaria. Evid Pediatr. 2008;4:20.
10/01/2009

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