December 2010. Volume 6. Number 4

Oral sucrose for procedural pain in neonates reduces crying, even though electroencephalography does not change

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Slater R, Cornelissen L, Fabrizi L, Patten D, Yoxen J, Worley A et al. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Lancet. 2010;6736:1-8.
Reviewers: Pérez Gaxiola G1, Cuello García CA2.
1Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
2ITESM. Monterrey. Nuevo León. México.
Correspondence: Giordano Pérez Gaxiola. Email: giordanopg@gmail.com
Reception date: 06/09/2010
Acceptance date: 08/09/2010
Publication date: 13/09/2010

Abstract

Authors conclusion: our results show that although oral sucrose does reduce observed pain behaviour, it has no significant effect on the magnitude of spinal nociceptive reflexes or on the acute activation of pain networks in the brain.

Reviewers commentary: sucrose is effective for reducing crying time and behaviours suggestive of pain in neonates, outcomes that are clinically important and patient oriented. Change in electroencephalography is a surrogate outcome.

Key words: analgesia; neonate; sucrose

How to cite this article

Pérez Gaxiola G, Cuello García CA. La sacarosa disminuye el llanto de neonatos durante procedimientos menores, aunque el electroencefalograma no se modifica. Evid Pediatr. 2010;6:76.

AVC | Critically appraised articles

Slater R, Cornelissen L, Fabrizi L, Patten D, Yoxen J, Worley A et al. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Lancet. 2010;6736:1-8.
Reviewers: Pérez Gaxiola G1, Cuello García CA2.
1Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
2ITESM. Monterrey. Nuevo León. México.
Correspondence: Giordano Pérez Gaxiola. Email: giordanopg@gmail.com
Key words: analgesia; neonate; sucrose
Reception date: 06/09/2010
Acceptance date: 08/09/2010
Publication date: 13/09/2010

How to cite this article

Pérez Gaxiola G, Cuello García CA. La sacarosa disminuye el llanto de neonatos durante procedimientos menores, aunque el electroencefalograma no se modifica. Evid Pediatr. 2010;6:76.

References

  1. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;1:CD001069.
  2. Stevens B, Johnston C, Petryshen P, Taddio A. Premature Infant Pain Profile: development and initial validation. Clin J Pain. 1996;12:13-22.
  3. Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, et al. Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review. Arch Dis Child. 2010;95:406-13.
  4. Holsti L, Grunau RE. Considerations for using sucrose to reduce procedural pain in preterm infants. Pediatrics. 2010;125:1042-7.

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ED | Non-pharmaological analgesia: the need to implement this practice in the routine care of newborns and infants during painful procedures

Soriano FJ. Analgesia no farmacológica: necesidad de implantar esta práctica en nuestra atención a recién nacidos y lactantes ante procedimientos dolorosos. Evid Pediatr. 2010;6:72.
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