December 2010. Volume 6. Number 4

Is there a relationship between prenatal Dichlorodiphenyldichloroethylene levels and lower respiratory tract infections in children under 14 months of age?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Sunyer J, Garcia-Esteban R, Alvarez M, Guxens M, Goñi F, Basterrechea M et al. DDE in Mothers’ Blood During Pregnancy and Lower Respiratory Tract Infections in Their Infants. Epidemiology. 2010;21:729-35.
Reviewers: Ortega Páez E1, de Lucas García N2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Hospital de Tomelloso. Tomelloso. Ciudad Real. España.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 19/10/2010
Acceptance date: 03/11/2010
Publication date: 11/11/2010

Abstract

Authors´ conclusions: the immune suppression by Dichlorodiphenyldichloroethylene (DDE) detected in previous experimental studies may explain the relationship between DDE and lower respiratory tract infection (LRTI). DDE exposure during prenatal life may be critical for the development of immune and respiratory system.

Reviewers´ commentary: although previous transverse studies have related DDE to different diseases in children, this study has methodological weaknesses that make it difficult to draw any definite conclusions about the association between prenatal DDE levels and infant LRTI. New high-quality studies would be needed in order to confirm this association.

How to cite this article

Ortega Páez E, de Lucas García N. ¿Existe relación entre los niveles prenatales de diclorodifenildicloroetileno y las infecciones respiratorias de vías bajas en menores de 14 meses? Evid Pediatr. 2010;6:75.

AVC | Critically appraised articles

Sunyer J, Garcia-Esteban R, Alvarez M, Guxens M, Goñi F, Basterrechea M et al. DDE in Mothers’ Blood During Pregnancy and Lower Respiratory Tract Infections in Their Infants. Epidemiology. 2010;21:729-35.
Reviewers: Ortega Páez E1, de Lucas García N2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Hospital de Tomelloso. Tomelloso. Ciudad Real. España.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 19/10/2010
Acceptance date: 03/11/2010
Publication date: 11/11/2010

How to cite this article

Ortega Páez E, de Lucas García N. ¿Existe relación entre los niveles prenatales de diclorodifenildicloroetileno y las infecciones respiratorias de vías bajas en menores de 14 meses? Evid Pediatr. 2010;6:75.

References

  1. Sagiv SK, Thurston SW, Bellinger DC, Tolbert PE, Altshul LM, Korrick SA. Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am J Epidemiol. 2010;17:593-601.
  2. Sunyer J, Torrent M, Muñoz-Ortiz L, Ribas-Fitó N, Carrizo D, Grimalt J et al. Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ Health Perspect. 2005;113:1787-90.
  3. Mariscal-Arcas M, Lopez-Martinez C, Granada A, Olea N, Lorenzo-Tovar ML, Olea-Serrano F. Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet. Food Chem Toxicol. 2010;48:1311-5.
11/11/2010

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