September 2012. Volume 8. Number 3

Hypertonic saline is not useful for children younger than 6 years with cystic fibrosis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, et al; Isis Study Group FT. Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial. JAMA. 2012;307:2269-77.
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 23/07/2012
Acceptance date: 24/07/2012
Publication date: 01/08/2012

Abstract

Authors’ conclusions: among infants and children younger than 6 years with cystic fibrosis, the use of inhaled hypertonic saline compared with isotonic saline did not reduce the rate of pulmonary exacerbations over the course of 48 weeks of treatment.

Reviewers’ comment: regarding the results of this study, that shows no efficacy of inhaled hypertonic saline in the reduction of exacerbations amongst children younger than 6 years with cystic fibrosis, this therapy shouldn’t be used in these patients. More studies are necessary to assess the effect over other outcomes or disease progression.

How to cite this article

Gimeno Díaz de Atauri A, Rivas Juesas C. El suero salino hipertónico no es eficaz en niños menores de seis años con fibrosis quística. Evid Pediatr. 2012;8:59.

AVC | Critically appraised articles

Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, et al; Isis Study Group FT. Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial. JAMA. 2012;307:2269-77.
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 23/07/2012
Acceptance date: 24/07/2012
Publication date: 01/08/2012

How to cite this article

Gimeno Díaz de Atauri A, Rivas Juesas C. El suero salino hipertónico no es eficaz en niños menores de seis años con fibrosis quística. Evid Pediatr. 2012;8:59.

References

  1. Borowitz D, Robinson KA, Rosenfeld M, Davis SD, Sabadosa KA, Spear SL, et al. Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis. J Pediatr. 2009;155:S73-93.
  2. Wark P, McDonald VM. Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev. 2009;(2):CD001506.
  3. Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, et al; EPIC Study Group Participating Clinical Sites. Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort. Pediatr Pulmonol. 2010;45:934-44.
  4. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks GB, et al; National Hypertonic Saline in Cystic Fibrosis (NHSCF) Study Group. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med. 2006;354:229-40.
  5. Laube BL, Sharpless G, Carson KA, Kelly A, Mogayzel PJ Jr. Acute inhalation of hypertonic saline does not improve mucociliary clearance in all children with cystic fibrosis. BMC Pulm Med. 2011;11:45.
01/08/2012

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