December 2012. Volume 8. Number 4

Inhaled glucocorticoids can decrease slightly the attained adult height

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, et al. for the CAMP Research Group. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. N Engl J Med. 2012;367:904-12
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 12/10/2012
Acceptance date: 14/10/2012
Publication date: 17/10/2012

Abstract

Authors' conclusions: treatment with inhaled glucocorticoids reduces growth amongst prepuberal children in the first two years, what is associated with a lower adult height.

Reviewers' commentary: inhaled glucocorticoids have shown efficacy in reducing asthma symptoms. The possible effects on adult height do not seem to be important enough to waive their benefits but it is useful to remind that its use is not completely free of adverse events and that they should be avoided in patients with sporadic symptoms in whom the risks probably outweight the benefits.

How to cite this article

Rivas Juesas C, Gimeno Díaz de Atauri A. Los corticoides inhalados pueden disminuir discretamente la talla adulta. Evid Pediatr. 2012;8:76.

AVC | Critically appraised articles

Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, et al. for the CAMP Research Group. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. N Engl J Med. 2012;367:904-12
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 12/10/2012
Acceptance date: 14/10/2012
Publication date: 17/10/2012

How to cite this article

Rivas Juesas C, Gimeno Díaz de Atauri A. Los corticoides inhalados pueden disminuir discretamente la talla adulta. Evid Pediatr. 2012;8:76.

References

  1. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med. 2000;343:1054-63.
  2. Strunk RC, Sternberg AL, Szefler SJ, Zeiger RS, Bender B, Tonascia J; Childhood Asthma Management Program (CAMP) Research Group. Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. J Pediatr. 2009;154:682-7.
  3. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2011 [en línea] [fecha de consulta: 10-12-2012]. Disponible en: http://www.ginasthma.org/
  4. BTS/SIGN Asthma Guideline: 2011 [en línea] [fecha de consulta: 10-12-2012]. Disponible en: http://www.brit-thoracic.org.uk/guidelines
  5. Managing asthma long term in children 0-4 years of age and 5-11 years of age. En: National Asthma Education and Prevention Program (NAEPP). Expert panel report 3: guidelines for the diagnosis and management of asthma. Bethesda (MD): National Heart, Lung, and Blood Institute; 2007 Aug. p. 281-325.
  6. Sharek P, Bergman D, Ducharme F. Beclometasona para el asma en niños: efectos sobre el crecimiento lineal (Revision Cochrane traducida). Cochrane Database of Systematic Reviews 2011 Issue 7. Art. No.: CD001282. DOI: 10.1002/14651858.CD001282.
  7. Agertoft L, Pedersen S. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med. 2000;343:1064-9.
  8. Guilbert TW, Mauger DT, Allen DB, Zeiger RS, Lemanske RF Jr, Szefler SJ, et al.; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol. 2011;128:956-63.
  9. Bensch GW, Greos LS, Gawchik S, Kpamegan E, Newman KB. Linear growth and bone maturation are unaffected by 1 year of therapy with inhaled flunisolide hydrofluoroalkane in prepubescent children with mild persistent asthma: a randomized, double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol. 2011;107:323-9.

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Linked Comment

CA | Inhaled glucocorticoids for asthma during childhood and adult height

Praena Crespo M. Los corticoides inhalados para el tratamiento del asma en la infancia y la talla adulta. Evid Pediatr. 2012;8:83.