September 2013. Volume 9. Number 3

The use of antibiotics during pregnancy may increase the risk of childhood asthma

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Stensballe LG, Simonsen J, Jensen SM,  Bønnelykke K,  Bisgaard H. Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood. J Pediatr. 2013;162:832-8.
Reviewers: Rivas Juesas C1, García Vera C2.
1Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
2CS Sagasta-Ruiseñores. Zaragoza. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 03/08/2013
Acceptance date: 05/08/2013
Publication date: 04/09/2013

Abstract

Authors' conclusions: there's an increased risk of asthma within the first five years of life in high risk children whose mothers received antibiotics in the third trimester of gestation. These findings are supported by a national cohort with unselected children.

Reviewers' commentary: the rational use of antibiotics during pregnancy in mothers with history of asthma could decrease the incidence of asthma in their children. Nevertheless, more studies are needed to confirm this association and the real impact in child's health.

How to cite this article

Rivas Juesas C, García Vera C. El uso de antibióticos durante la gestación podría aumentar el riesgo de padecer asma infantil. Evid Pediatr. 2013;9:51.

AVC | Critically appraised articles

Stensballe LG, Simonsen J, Jensen SM,  Bønnelykke K,  Bisgaard H. Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood. J Pediatr. 2013;162:832-8.
Reviewers: Rivas Juesas C1, García Vera C2.
1Servicio de Pediatría. Hospital de Sagunto. Sagunto. Valencia. España.
2CS Sagasta-Ruiseñores. Zaragoza. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 03/08/2013
Acceptance date: 05/08/2013
Publication date: 04/09/2013

How to cite this article

Rivas Juesas C, García Vera C. El uso de antibióticos durante la gestación podría aumentar el riesgo de padecer asma infantil. Evid Pediatr. 2013;9:51.

References

  1. Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS One. 2010;5(1):e8578.
  2. Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bønnelykke K, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357:1487-95.
  3. Benn CS, Thorsen P, Jensen JS, Kjaer BB, Bisgaard H, Andersen M, et al. Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood. J Allergy Clin Immunol. 2002;110:72-7.
  4. Dom S, Droste JH, Sariachvili MA, Hagendorens MM, Oostveen E, Bridts CH, et al. Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years. Clin Exp Allergy. 2010;40:1378-87.
  5. Bisgaard H. The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol. 2004;93(4):381-9.
04/09/2013

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