March 2014. Volume 10. Number 1

Una prueba rápida puede reducir la morbimortalidad por sepsis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Buchan BW, Ginocchio CC, Manii R, Cavagnolo R, Pancholi P, Swyers L, et al. Multiplex identification of gram-positive bacteria and resistance determinants directly from positive blood culture broths: evaluation of an automated microarray-based nucleic acid test. PLoS Med. 2013;10:e1001478.
Reviewers: Perdikidis Olivieri L1, Carvajal Encina F2.
1EAP Juncal. Torrejón de Ardoz. Madrid. España.
2UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
Correspondence: Leo Perdikidis Olivieri. Email: lperdikidis@gmail.com
Reception date: 22/01/2014
Acceptance date: 30/01/2014
Publication date: 19/02/2014

Abstract

Authors' conclusions: the Verigene Gram-Positive Blood Culture Test is useful for the early diagnosis of sepsis, with a high sensitivity and specificity.

Reviewers' conclusions: genetic tests are sophisticated tools that are very useful in the diagnosis of diseases. This has an impact on treatment and prognosis of disease since it is known that early and adequate antibiotic treatment for sepsis reduces morbidity and mortality.

Future studies need to determine the real impact of this test when applied to patients and morbimortality is evaluated. Nevertheless, blood culture continues to be mandatory in these cases. It is probable that the cost/benefit analysis proves favourable since reductions in morbimortality in a severe disease as is sepsis can have an important impact on costs for the health care system and for patients on the long run.

How to cite this article

Perdikidis Olivieri L, Carvajal Encina F. Una prueba rápida puede reducir la morbimortalidad por sepsis. Evid Pediatr. 2014;10:12.

AVC | Critically appraised articles

Buchan BW, Ginocchio CC, Manii R, Cavagnolo R, Pancholi P, Swyers L, et al. Multiplex identification of gram-positive bacteria and resistance determinants directly from positive blood culture broths: evaluation of an automated microarray-based nucleic acid test. PLoS Med. 2013;10:e1001478.
Reviewers: Perdikidis Olivieri L1, Carvajal Encina F2.
1EAP Juncal. Torrejón de Ardoz. Madrid. España.
2UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
Correspondence: Leo Perdikidis Olivieri. Email: lperdikidis@gmail.com
Reception date: 22/01/2014
Acceptance date: 30/01/2014
Publication date: 19/02/2014

How to cite this article

Perdikidis Olivieri L, Carvajal Encina F. Una prueba rápida puede reducir la morbimortalidad por sepsis. Evid Pediatr. 2014;10:12.

References

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  3. Buchan BW, Ginocchio CC, Manii R, Cavagnolo R, Pancholi P, Swyers L, et al. Multiplex Identification of Gram-Positive Bacteria and Resistance Determinants Directly from Positive Blood Culture Broths: Evaluation of an Automated Microarray-Based Nucleic Acid Test. PLoS Med. 2013;10:e1001478.
  4. Sullivan KV, Turner NN, Roundtree SS, Young S, Brock-Haag CA, Lacey D, et al. Rapid Detection of Gram-Positive Organisms Using the Verigene Gram-Positive Blood Culture Nucleic Acid Test and the BacT/ALERT Pediatric FAN System in a Multi-Centered Pediatric Evaluation. J Clin Microbiol. 2013;21:3579-84.
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19/02/2014

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