December 2013. Volume 9. Number 4

There is evidence that Pandemrix® (influenza A/H1N1, ASO3 adjuvanted vaccine) can hasten narcolepsy

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Miller E, Andrews N, Stellitano L, Stowe J, Winstone AM, Shneerson J, et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ. 2013;346:794.
Reviewers: Aparicio Rodrigo M1, Esparza Olcina MJ2.
1Centro de Salud Entreví­as. Área 1. Madrid. España.
2Centro de Salud Barcelona. Móstoles. Madrid. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Reception date: 02/10/2013
Acceptance date: 08/10/2013
Publication date: 16/10/2013

Abstract

Authors’ conclusions: there is an increased risk of narcolepsy in children vaccinated with pandemic A/H1N1 2009 Pandemrix® in England.

Reviewers’ commentary: the available data suggest a special personal or population predisposition to some components of this vaccine. It seems adequate the interruption of commercialization of Pandemrix® by European Medicines Agency, although causality is not totally proved and the risk may have been overestimated.

How to cite this article

Aparicio Rodrigo M, Esparza Olcina MJ. Existe evidencia de que Pandemrix® (vacuna contra la gripe A/H1N1 con ASO3) puede precipitar el desarrollo de narcolepsia. Evid Pediatr. 2013;9:67.

AVC | Critically appraised articles

Miller E, Andrews N, Stellitano L, Stowe J, Winstone AM, Shneerson J, et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ. 2013;346:794.
Reviewers: Aparicio Rodrigo M1, Esparza Olcina MJ2.
1Centro de Salud Entreví­as. Área 1. Madrid. España.
2Centro de Salud Barcelona. Móstoles. Madrid. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Reception date: 02/10/2013
Acceptance date: 08/10/2013
Publication date: 16/10/2013

How to cite this article

Aparicio Rodrigo M, Esparza Olcina MJ. Existe evidencia de que Pandemrix® (vacuna contra la gripe A/H1N1 con ASO3) puede precipitar el desarrollo de narcolepsia. Evid Pediatr. 2013;9:67.

References

  1. Mignot E. Genetic and familial aspects of narcolepsy. Neurology. 1998;50(2 Suppl 1):S16–S22.
  2. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoSOne. 2012;7:e33536.
  3. European Centre for Disease Prevention and Control. Narcolepsy in association with pandemic influenza vaccination (a multi-country European epidemiological investigation). Stockholm: ECDC; September 2012.
  4. Wijnans L, Lecomte C, de Vries C, Weibel D, Sammon C, Hviid A, et al. The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1) pdm09 pandemic and vaccination campaigns. Vaccine. 2013;31:1246-54.
  5. European Medicines Agency. Reviews hypothesis on Pandemrix and development of narcolepsy. EMA/CHMP/676755/2012.
16/10/2013

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