March 2019. Volume 15. Number 1

Echinocandins are an alternative of similar efficacy to amphotericin B in invasive candidiasis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, Kolios G, Roilides E. Efficacy and safety of echinocandins for the treatment of invasive candidiasis in children: a meta-analysis. Pediatr Infect Dis J. 2019;38:42-9.

Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Complejo Asistencial Universitario de Palencia. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jm.andres.dellano@gmail.com
Reception date: 18/03/2019
Acceptance date: 22/03/2019
Publication date: 27/03/2019

Abstract

Authors’s conclusions: the results of this meta-analysis indicate that echinocandins show non-inferior efficacy compared with amphotericin B formulations, with better compliance than in the control group, when used for the treatment of invasive candidiasis in children.

Reviewer’s commentary: the available experimental evidence on the comparative efficacy of echinocandins with respect to amphotericin B is of low quality because of imprecision. They do not seem to be less effective and, although the clinical trials have not shown less adverse events, the better lower rate of treatment withdrawal suggests that they have advantages of tolerance.

How to cite this article

Andrés de Llano JM, Ochoa Sangrador C. Las equinocandinas son una alternativa de eficacia similar a la anfotericina B en candidiasis invasiva. Evid Pediatr. 2019;15:10.

AVC | Critically appraised articles

Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, Kolios G, Roilides E. Efficacy and safety of echinocandins for the treatment of invasive candidiasis in children: a meta-analysis. Pediatr Infect Dis J. 2019;38:42-9.

Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Complejo Asistencial Universitario de Palencia. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jm.andres.dellano@gmail.com
Reception date: 18/03/2019
Acceptance date: 22/03/2019
Publication date: 27/03/2019

How to cite this article

Andrés de Llano JM, Ochoa Sangrador C. Las equinocandinas son una alternativa de eficacia similar a la anfotericina B en candidiasis invasiva. Evid Pediatr. 2019;15:10.

27/03/2019

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