June 2020. Volume 16. Number 2

Vaccinating infants younger than 9 months against measles in risky settings may be indicated

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Nic Lochlainn LM, de Gier B, van der Maas N, van Binnendijk R, Strebel PM, Goodman T, et al. Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis. Lancet Infect Dis. 2019;19:1246-54.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1Pediatra. CS Virgen de África. Sevilla. España.
2Pediatra. CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 14/05/2020
Acceptance date: 21/05/2020
Publication date: 03/06/2020

Abstract

Authors’ conclusions: administration of the first attenuated dose of measles vaccine before the 9th month, followed by one or two subsequent doses, results in an immune response similar to that other with an administration regimen with the first dose above 9 months, although there is some evidence of lower antibody titers in the first case. The relevance of this finding is uncertain.

Reviewers’ commentary: according to the results of the review, there are data in favor of the use of the first dose of attenuated measles vaccine at ages prior to 9 months, in the event of community outbreaks of the disease, but uncertainty arises as to whether this practice is appropriate in the long term.

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. Vacunar a menores de 9 meses de sarampión en entornos de riesgo podría estar indicado. Evid Pediatr. 2020;16:26.

AVC | Critically appraised articles

Nic Lochlainn LM, de Gier B, van der Maas N, van Binnendijk R, Strebel PM, Goodman T, et al. Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis. Lancet Infect Dis. 2019;19:1246-54.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1Pediatra. CS Virgen de África. Sevilla. España.
2Pediatra. CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 14/05/2020
Acceptance date: 21/05/2020
Publication date: 03/06/2020

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. Vacunar a menores de 9 meses de sarampión en entornos de riesgo podría estar indicado. Evid Pediatr. 2020;16:26.


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Hernández Merino A. Eliminación del sarampión: ¿estamos cerca o lejos del objetivo?, ¿hay que revisar la pauta vacunal actual? Evid Pediatr. 2020;16:14.
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