September 2021. Volume 17. Number 3

Metformin could be of help in the treatment of obesity

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Masarwa R, Brunetti VC, Aloe S, Henderson M, Platt RW, Filion KB. Efficacy and Safety of Metformin for Obesity: A Systematic Review. Pediatrics. 2021;147:e20201610.

Reviewers: Esparza Olcina MJ1, Fernández Rodríguez MM2.
1Pediatra de Atención Primaria. Madrid. España.
2CS Potes. SERMAS. Madrid. España.
Correspondence: María Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 30/08/2021
Acceptance date: 14/09/2021
Publication date: 29/09/2021

Abstract

Authors’ conclusions: metformin associated with lifestyle interventions may have a small favorable effect on BMI z-score and insulin resistance. It shows an acceptable safety profile in children and adolescents with obesity. The quality of the available evidence is variable.

Reviewers’ commentary: obesity drug therapy could help to achieve targets in the short and medium term, but the effect in the long term remains unknown. Metformin has a modest effect on BMI and produces frequent gastrointestinal adverse events that could reduce completion of treatments. Individual use of metformin could be proposed in specific obesity cases, especially if they present metabolic consequences.

How to cite this article

Esparza Olcina MJ, Fernández Rodríguez MM. La metformina podría ser un apoyo en el tratamiento de la obesidad. Evid Pediatr. 2021;17:33.

AVC | Critically appraised articles

Masarwa R, Brunetti VC, Aloe S, Henderson M, Platt RW, Filion KB. Efficacy and Safety of Metformin for Obesity: A Systematic Review. Pediatrics. 2021;147:e20201610.

Reviewers: Esparza Olcina MJ1, Fernández Rodríguez MM2.
1Pediatra de Atención Primaria. Madrid. España.
2CS Potes. SERMAS. Madrid. España.
Correspondence: María Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 30/08/2021
Acceptance date: 14/09/2021
Publication date: 29/09/2021

How to cite this article

Esparza Olcina MJ, Fernández Rodríguez MM. La metformina podría ser un apoyo en el tratamiento de la obesidad. Evid Pediatr. 2021;17:33.

29/09/2021

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