December 2023. Volume 19. Number 4

A rapid multiplex genetic detection test in meningoencephalitis reduces the duration of antiviral treatment, but not the hospital stay

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Berkhout A, Cheng DR, McNab S, Lee l, Daley AJ, Clifford V. Clinical and Health System Impact of Biofire Filmarray Meningitis/Encephalitis Routine Testing of CSF in a Pediatric Hospital. Pediatr Infect Dis J. 2023;42:281-5.

Reviewers: Flores Villar S1, Ochoa Sangrador C2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Servicio de Pediatría. Complejo Asistencial de Zamora. Zamora. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 04/10/2023
Acceptance date: 11/10/2023
Publication date: 08/11/2023

Abstract

Authors´ conclusions: the introduction of the rapid diagnostic test (Biofire FilmArray® Meningitis/Encephalitis) of cerebrospinal fluid samples in encephalitis and meningitis in infants under three months can reduce the duration of the prescription of antivirals, but not the total time of antibiotic use, nor the days of hospitalization. This laboratory test should be supported by protocols discussed and agreed upon by the different medical societies involved to optimize their use.

Reviewers´ commentary: the evidence on the clinical impact of the use of multiple genetic detection tests in pediatric meningoencephalitis is of low quality, due to imprecision and methodological limitations. Before assuming their systematic use, we must evaluate their clinical performance, ideally with protocols that direct decision-making based on the positive or negative results of each component of the diagnostic panel.

How to cite this article

Flores Villar S, Ochoa Sangrador C. Una prueba rápida de detección genética múltiple en meningoencefalitis reduce la duración del tratamiento antiviral, pero no la estancia hospitalaria. Evid Pediatr. 2023;19:42.

AVC | Critically appraised articles

Berkhout A, Cheng DR, McNab S, Lee l, Daley AJ, Clifford V. Clinical and Health System Impact of Biofire Filmarray Meningitis/Encephalitis Routine Testing of CSF in a Pediatric Hospital. Pediatr Infect Dis J. 2023;42:281-5.

Reviewers: Flores Villar S1, Ochoa Sangrador C2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Servicio de Pediatría. Complejo Asistencial de Zamora. Zamora. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 04/10/2023
Acceptance date: 11/10/2023
Publication date: 08/11/2023

How to cite this article

Flores Villar S, Ochoa Sangrador C. Una prueba rápida de detección genética múltiple en meningoencefalitis reduce la duración del tratamiento antiviral, pero no la estancia hospitalaria. Evid Pediatr. 2023;19:42.

08/11/2023

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