December 2024. Volume 20. Number 4

Paracetamol and neurodevelopment: new data on the safety of its use during pregnancy

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Ahlqvist VH, Sjöqvist H, Dalman C, Karlsson K, Stephansson O, Johansson S, et al. Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331:1205-14.

Reviewers: Fernández Rodríguez MM1, Aparicio Sánchez JL2.
1CS Potes. SERMAS. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: M.ª Mercedes Fernández Rodríguez. Email: mer763@gmail.com
Reception date: 02/12/2024
Acceptance date: 16/12/2024
Publication date: 26/12/2024

Abstract

Authors’ conclusions: acetaminophen use during pregnancy was not associated with children's risk of autism, ADHD, or intellectual disability in sibling control analysis. This suggests that associations observed in other models may have been attributable to familial confounding.

Reviewers' commentary: this population-based cohort study adjusts for confounding factors including the use of other drugs during pregnancy, their indications and the influence on unexposed siblings. The results do not question the safety of acetaminophen use during pregnancy in relation to these neurodevelopmental alterations. The possibility of using this analgesic may be of benefit to pregnant women who need to treat pain or fever during pregnancy.

How to cite this article

Fernández Rodríguez MM, Aparicio Sánchez JL. Paracetamol y neurodesarrollo: nuevos datos sobre la seguridad de su empleo durante el embarazo. Evid Pediatr. 2024;20:52.

AVC | Critically appraised articles

Ahlqvist VH, Sjöqvist H, Dalman C, Karlsson K, Stephansson O, Johansson S, et al. Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331:1205-14.

Reviewers: Fernández Rodríguez MM1, Aparicio Sánchez JL2.
1CS Potes. SERMAS. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: M.ª Mercedes Fernández Rodríguez. Email: mer763@gmail.com
Reception date: 02/12/2024
Acceptance date: 16/12/2024
Publication date: 26/12/2024

How to cite this article

Fernández Rodríguez MM, Aparicio Sánchez JL. Paracetamol y neurodesarrollo: nuevos datos sobre la seguridad de su empleo durante el embarazo. Evid Pediatr. 2024;20:52.

26/12/2024

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