June 2026. Volume 22. Number 2

Is the use of montelukast associated with an increased risk of neuropsychiatric events in children?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wintzell V, Brenner P, Halldner L, Rhedin S, Gong T, Almqvist C. Montelukast Use and the Risk of Neuropsychiatric Adverse Events in Children. JAMA Pediatr. 2025;179(4):418-27.

Reviewers: Moreno Sánchez A1, Albi Rodríguez MS2.
1Pediatra. CS de Leitza. Navarra. España.
2Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
Correspondence: Amelia Moreno Sánchez. Email: ameliamorenosanchez111@gmail.com
Reception date: 13/04/2026
Acceptance date: 21/04/2026
Publication date: 29/04/2026

Abstract

Authors´ conclusions: based on routine clinical practice data, no increased risk of neuropsychiatric events has been found in children and adolescents treated with montelukast.

Reviewers´ commentary: the study follows an appropriate methodology, providing safety data for treatment with montelukast; however, not enough to stop the surveillance against these possible events.

How to cite this article

Moreno Sánchez A, Albi Rodríguez MS. ¿El uso de montelukast se asocia con un mayor riesgo de eventos neuropsiquiátricos en niños? Evid Pediatr. 2026;22:13.

AVC | Critically appraised articles

Wintzell V, Brenner P, Halldner L, Rhedin S, Gong T, Almqvist C. Montelukast Use and the Risk of Neuropsychiatric Adverse Events in Children. JAMA Pediatr. 2025;179(4):418-27.

Reviewers: Moreno Sánchez A1, Albi Rodríguez MS2.
1Pediatra. CS de Leitza. Navarra. España.
2Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
Correspondence: Amelia Moreno Sánchez. Email: ameliamorenosanchez111@gmail.com
Reception date: 13/04/2026
Acceptance date: 21/04/2026
Publication date: 29/04/2026

How to cite this article

Moreno Sánchez A, Albi Rodríguez MS. ¿El uso de montelukast se asocia con un mayor riesgo de eventos neuropsiquiátricos en niños? Evid Pediatr. 2026;22:13.

29/04/2026

Linked Comment

Methodological note