June 2026. Volume 22. Number 2

Gender affirming hormone therapy: what evidence do we have so far?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Miroshnychenko A, Ibrahim S, Roldan Y, Kulatunga-Moruzi C, Montante S, Couban R, et al. Gender affirming hormone therapy for individuals with gender dysphoria aged <26 years: a systematic review and meta-analysis. Arch Dis Child.2025;110:437-45.

Reviewers: Gámez Belmonte A1, Rivero Martín MJ2.
1Servicio de Pediatría. Hospital de Antequera. Antequera. Málaga. España.
2Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Fuenlabrada. Madrid. España.
Correspondence: Ana Gámez Belmonte. Email: ana_gamez_@hotmail.com
Reception date: 20/04/2026
Acceptance date: 28/04/2026
Publication date: 13/05/2026

Abstract

Authors’ conclusions: there is a great uncertainty around the gender affirming hormone therapy and further studies with rigorous methodology are needed.

Reviewers’ commentary: gender affirmation therapy cannot be accepted or rejected with the results this systematic review provides, since the evidence of the included studies is low or very low.

How to cite this article

Gámez Belmonte A, Rivero Martín MJ. Tratamiento hormonal de afirmación de género: ¿de qué evidencias disponemos por ahora? Evid Pediatr. 2026;22:15.

AVC | Critically appraised articles

Miroshnychenko A, Ibrahim S, Roldan Y, Kulatunga-Moruzi C, Montante S, Couban R, et al. Gender affirming hormone therapy for individuals with gender dysphoria aged <26 years: a systematic review and meta-analysis. Arch Dis Child.2025;110:437-45.

Reviewers: Gámez Belmonte A1, Rivero Martín MJ2.
1Servicio de Pediatría. Hospital de Antequera. Antequera. Málaga. España.
2Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Fuenlabrada. Madrid. España.
Correspondence: Ana Gámez Belmonte. Email: ana_gamez_@hotmail.com
Reception date: 20/04/2026
Acceptance date: 28/04/2026
Publication date: 13/05/2026

How to cite this article

Gámez Belmonte A, Rivero Martín MJ. Tratamiento hormonal de afirmación de género: ¿de qué evidencias disponemos por ahora? Evid Pediatr. 2026;22:15.

13/05/2026

Linked Comment

Methodological note