September 2026. Volume 22. Number 3

Mass Administration of Azithromycin in Mali, in infants 1 to 11 months of age, did not result in lower mortality

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Haidara FC, Adubra l, Abdou M, Alber D, Ashorn U, Cheung YB, et al. Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality. N Engl J Med. 2025;393:1498-508.

Reviewers: Pérez Solís D1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Universitario de Cabueñes. Gijón. Asturias. España.
2Pediatra. CS Barrio del Pilar. Madrid. España.
Correspondence: David Pérez Solís. Email: david@perezsolis.es
Reception date: 06/07/2026
Acceptance date: 13/07/2026
Publication date: 22/07/2026

Abstract

Authors´ conclusions: mass administration of azithromycin in Mali, limited to infants 1 to 11 months of age, did not result in lower infant or child mortality than placebo, regardless of whether azithromycin was delivered twice yearly or quarterly.

Reviewers´ commentary: infant mortality in the poorest countries could be reduced through the administration of azithromycin several times a year. Its effect would be related to a reduction in infections. In this study, the use in children aged 1 to 11 months does not appear to influence reducing mortality. This lack of effect, together with the potential increase in antimicrobial resistance, makes it advisable to seek new strategies to decrease infant mortality.

How to cite this article

Pérez Solís D, González Rodríguez P. La administración masiva de azitromicina a lactantes de 1 a 11 meses en Mali no redujo la mortalidad. Evid Pediatr. 2026;22:27.

AVC | Critically appraised articles

Haidara FC, Adubra l, Abdou M, Alber D, Ashorn U, Cheung YB, et al. Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality. N Engl J Med. 2025;393:1498-508.

Reviewers: Pérez Solís D1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Universitario de Cabueñes. Gijón. Asturias. España.
2Pediatra. CS Barrio del Pilar. Madrid. España.
Correspondence: David Pérez Solís. Email: david@perezsolis.es
Reception date: 06/07/2026
Acceptance date: 13/07/2026
Publication date: 22/07/2026

How to cite this article

Pérez Solís D, González Rodríguez P. La administración masiva de azitromicina a lactantes de 1 a 11 meses en Mali no redujo la mortalidad. Evid Pediatr. 2026;22:27.

22/07/2026

Linked Comment

Methodological note