March 2009. Volume 5. Number 1

A deeper approach on the knowledge of asthma phenotypes in childhood

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Henderson J, Granell R, Heron J, Sherriff A, Simpson A, Woodcock A, et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid- childhood. Thorax. 2008;63;974-80
Reviewers: Rivas Juesas C1, González de Dios J2.
1Servicio de Pediatría. Hospital de Sagunto. Valencia. Valencia. España.
2Departamento de Pediatrí­a. Hospital General Universitario de Alicante. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 31/01/2009
Acceptance date: 06/02/2009
Publication date: 08/02/2009

Abstract

Authors' conclusions: this study describes six asthma phenotypes in childhood. Three of them, characterised by the onset of wheezing in children of more than 18 months of age, are strongly related to atopy. There seems to be environmental influences on the appearance of atopic wheezing during the first years of life on individuals genetically prone to develop asthma.

Reviewers' comantary: this study represents the most important population cohort study for understanding the heterogeneity of asthma since the publication of the Tucson study in 1995. It shows three new phenotypes in asthmatic patients. Besides, it is an outstanding study to improve our practice because it allows us to perform some allergic test in children with real risk of atopic asthma.
Profundizando en el conocimiento de los fenotipos del asma infantil

How to cite this article

Rivas Juesas C, González de Dios J. Profundizando en el conocimiento de los fenotipos del asma infantil. Evid Pediatr. 2009;5:15.

AVC | Critically appraised articles

Henderson J, Granell R, Heron J, Sherriff A, Simpson A, Woodcock A, et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid- childhood. Thorax. 2008;63;974-80
Reviewers: Rivas Juesas C1, González de Dios J2.
1Servicio de Pediatría. Hospital de Sagunto. Valencia. Valencia. España.
2Departamento de Pediatrí­a. Hospital General Universitario de Alicante. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 31/01/2009
Acceptance date: 06/02/2009
Publication date: 08/02/2009

How to cite this article

Rivas Juesas C, González de Dios J. Profundizando en el conocimiento de los fenotipos del asma infantil. Evid Pediatr. 2009;5:15.

References

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  4. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483-91.
  5. Elphick HE, Sherlock P, Foxall G, Simpson EJ, Shiell NA, Primhak RA, et al. Survey of respiratory sounds in infants. Arch Dis Child. 2001;84:35-9.
08/02/2009

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