March 2009. Volume 5. Number 1

Intravenous dexamethasone may increase the risk of post-operative bleeding in children undergoing adeno-tonsillectomy

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Czarnetzki C. Elia N., Lysakowski C , Dumont L, Landis BN, Giger R, et al. Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children A Randomized Trial. JAMA. 2008;300(22):2621-30
Reviewers: Carvajal Encina F1, Buñuel Álvarez JC2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 04/02/2009
Acceptance date: 10/02/2009
Publication date: 12/02/2009

Abstract

Authors' conclusions: Intravenous dexamethasone reduces the risk of nausea and vomiting during the postoperative days after tonsillectomy (with or without adenoidectomy) in a dose-dependent way, but it is associated to an increased risk of postoperative bleeding in the following ten days.

Reviewers' comantary: The results of this study discourage the routine use of dexamethasone, particularly at doses of 0.5 mg / kg in patients undergoing adenoidectomy and / or tonsillectomy because the risk of bleeding within ten days implies an unfavorable risk-benefit profile.

How to cite this article

Carvajal Encina F, Buñuel Álvarez JC. En niños sometidos a adeno-amigdalectomía, la dexametasona intravenosa puede aumentar el riesgo de hemorragia post-operatoria. Evid Pediatr. 2009;5:19.

AVC | Critically appraised articles

Czarnetzki C. Elia N., Lysakowski C , Dumont L, Landis BN, Giger R, et al. Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children A Randomized Trial. JAMA. 2008;300(22):2621-30
Reviewers: Carvajal Encina F1, Buñuel Álvarez JC2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 04/02/2009
Acceptance date: 10/02/2009
Publication date: 12/02/2009

How to cite this article

Carvajal Encina F, Buñuel Álvarez JC. En niños sometidos a adeno-amigdalectomía, la dexametasona intravenosa puede aumentar el riesgo de hemorragia post-operatoria. Evid Pediatr. 2009;5:19.

References

  1. Steward DL, Welge JA, Myer CM. Esteroides para mejorar la recuperación posterior a la amigdalectomía en niños (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com. (Traducida de The Cochrane Library, 2008 Issue 2. Chichester, UK: John Wiley & Sons, Ltd.).
  2. Bolton CM, Myles PS, Nolan T, Sterne JA. Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. Br J Anaesth. 2006;97:593-604.
12/02/2009

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