July 2010. Volume 6. Number 2

Ibuprofen is effective in closing a patent ductus arteriosus in preterm newborns, and it could produce less adverse effects than indomethacin

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD003481.
Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jmandres@ono.com
Acceptance date: 09/06/2010
Publication date: 21/06/2010

Abstract

Authors’ conclusions: Ibuprofen is effective in closing a patent ductus arteriosus. Ibuprofen is as effective as indomethacin in closing a ductus and reduces the risk of necrotizing enterocolitis and transient renal insufficiency. Ibuprofen could be the drug of choice, although studies are needed to evaluate the effect of the Ibuprofen treatment compared to indomethacin on long-term outcomes.

Reviewers’ commentary: the use of ibuprofen seems to be safe and effective in closing a ductus with fewer side effects than indomethacin. Studies with more number of patients are needed to evaluate the effect on long-term outcomes.

How to cite this article

Andrés de Llano JM, Ochoa Sangrador C. El ibuprofeno es eficaz en el cierre del conducto arterioso persistente en el recién nacido pretérmino y presenta menos efectos secundarios que la indometacina. Evid Pediatr. 2010;6:30.

AVC | Critically appraised articles

Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD003481.
Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jmandres@ono.com
Acceptance date: 09/06/2010
Publication date: 21/06/2010

How to cite this article

Andrés de Llano JM, Ochoa Sangrador C. El ibuprofeno es eficaz en el cierre del conducto arterioso persistente en el recién nacido pretérmino y presenta menos efectos secundarios que la indometacina. Evid Pediatr. 2010;6:30.

References

  1. Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R, et al. Variations in practice and outcomes in the Canadian NICU Network 1996-1997. Pediatrics. 2000;106:1070-9.
  2. Cotton RB, Stahlman MT, Kovar I, Catterton WZ. Medical management of small preterm infants with symptomatic patent ductus arteriosus. J Pediatr. 1978;92:467-73.
  3. Varvarigou A, Bardin CL, Beharry K, Chemtob S, Papageorgiou A, Aranda JV. Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants. JAMA. 1996;275:539-44.
  4. Guimarães H, Rocha G, Tomé T, Anatolitou F, Sarafidis K, Fanos V. Non-steroid anti-inflammatory drugs in the treatment of patent ductus arteriosus in European newborns. J Matern Fetal Neonatal Med. 2009;22(Suppl 3):77-80.
21/06/2010

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