June 2012. Volume 8. Number 2

Intramuscular midazolam is not inferior than intravenous lorazepam for the treatmentof prolonged seizures

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y et al.; NETT Investigators. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366:591-600.
Reviewers: Ramos Lizana J1, Buñuel Álvarez JC2.
1Unidad de Neurología Pediátrica. Hospital Torrecárdenas. Almería. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Julio Ramos Lizana. Email: jramoslizana@telefonica.net
Reception date: 16/04/2012
Acceptance date: 23/04/2012
Publication date: 03/05/2012

Abstract

Autors' conclussions: for outpatient treatment of seizures of more than 5 minutes duration, midazolamadministered intramuscularly is at least as effective and safe as intravenous lorazepam.

Reviewers' commentary: the main advantage of intramuscular midazolam is the ease of administration compared to intravenous route. The results of this study showed that this drug is not inferior to intravenous lorazepam. Therefore, intramuscular midazolam should be considered as an alternative of choice for treatment of prolonged seizures in the community setting.

How to cite this article

Ramos Lizana J, Buñuel Álvarez JC. Midazolam intramuscular no es inferior a lorazepam intravenoso para el tratamiento de las convulsiones prolongadas. Evid Pediatr. 2011;8:35.

AVC | Critically appraised articles

Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y et al.; NETT Investigators. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366:591-600.
Reviewers: Ramos Lizana J1, Buñuel Álvarez JC2.
1Unidad de Neurología Pediátrica. Hospital Torrecárdenas. Almería. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Julio Ramos Lizana. Email: jramoslizana@telefonica.net
Reception date: 16/04/2012
Acceptance date: 23/04/2012
Publication date: 03/05/2012

How to cite this article

Ramos Lizana J, Buñuel Álvarez JC. Midazolam intramuscular no es inferior a lorazepam intravenoso para el tratamiento de las convulsiones prolongadas. Evid Pediatr. 2011;8:35.

References

  1. Shinnar S, Berg AT, Moshe SL, Shinnar R. How long do new onset seizures in children last? Ann Neurol. 2001;49:559-64.
  2. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ et al. A comparison of four treatments for generalized convulsive status epilepticus. Veteran Affairs Status Epilepticus Cooperative Study Group. N Eng J Med. 1998;339:792-8.
  3. Appleton Richard, Macleod Stewart, Martland Timothy. Tratamiento farmacológico para las convulsiones agudas tonicoclónicas, incluido el estado epiléptico convulsivo en niños (Revisión Cochrane traducida). En: La Biblioteca CochranePlus, 2008. Número 4. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com (Traducida de The Cochrane Library, 2008 Issue 3. Chichester, UK: John Wiley & Sons, Ltd).
03/05/2012

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