March 2013. Volume 9. Number 1

Can gluten produce gastrointestinal symptoms in non-celiac patients?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Biesiekierski JR, Sci BA, Newnham ED, Irving PM, Barrett JS, Haines M, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-14.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología y Nutrición. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 20/01/2013
Acceptance date: 21/01/2013
Publication date: 23/01/2013

Abstract

Authors' conclusions: in subjects with irritable bowel syndrome who have their symptoms controlled after gluten-free diet, the gluten challenge is a trigger digestive symptoms and fatigue, without evidence of inflammation or intestinal damage.

Reviewers' commentary: irritable bowel syndrome is a very heterogeneous clinical entity whose diagnosis most often is by exclusion. To know the exact implication of gluten, it would take well-designed clinical trials with adequate sample size and strict diagnostic inclusion criteria to determine which group of patients with functional gastrointestinal symptoms could benefit from the exclusion of gluten from the diet.

How to cite this article

Molina Arias M, Ortega Páez E. ¿Produce el gluten síntomas en pacientes no celiacos? Evid Pediatr. 2013;9:8.

AVC | Critically appraised articles

Biesiekierski JR, Sci BA, Newnham ED, Irving PM, Barrett JS, Haines M, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-14.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología y Nutrición. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 20/01/2013
Acceptance date: 21/01/2013
Publication date: 23/01/2013

How to cite this article

Molina Arias M, Ortega Páez E. ¿Produce el gluten síntomas en pacientes no celiacos? Evid Pediatr. 2013;9:8.

References

  1. Newnham ED. Does gluten cause gastrointestinal symptoms in subjects without coeliac disease? J Gastroenterol Hepatol. 2011;26 (Suppl3):132-4.
  2. Carroccio A, Mansueto P, Iacono G, Soresi M, D’Alcamo A, Cavataio F, et al. Non-celiac wheat sensitivity diagnosed by doble-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol. 2012;107:1898-906.
  3. Massari S, Liso M, De Santis L, Mazzei F, Carlone A, Mauro S, et al. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. Int Arch Allergy Immunol. 2011;155:389-94.

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Díaz Marugán V, Magallares García L, Fernández Caamaño B, Alcolea Sánchez A, Alonso Canal L, Polanco Allue I. ¿Puede ser el gluten perjudicial en pacientes no celiacos? Evid Pediatr. 2013;9:1.
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