December 2013. Volume 9. Number 4

Hepatitis B vaccination response could be influenced by HLA system

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Li ZK, Nie JJ, Li J, Zhuang H. The effect of HLA on immunological response to hepatitis B vaccine in healthy people: A meta-analysis. Vaccine. 2013;31:4355-61.
Reviewers: Ortega Páez E1, Molina Arias M2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 06/10/2013
Acceptance date: 17/10/2013
Publication date: 27/11/2013

Abstract

Authors' conclusions: specific HLA alleles (DRB1 and DQB1) are associated with antibody response to hepatitis B vaccination.

Reviewers' commentary: although the influence of HLA system in the immune response to the hepatitis B vaccine is something well established, the practice of the systematic HLA determination, prior to vaccination, to identify presumable responders to the vaccine is considered as something of little use in the daily practice, and it should be relegated to individuals with a special risk of suffering from hepatitis B.

How to cite this article

Ortega Páez E, Molina Arias M. La respuesta a la vacunación de la hepatitis B puede estar condicionada por el sistema HLA. Evid Pediatr. 2013;9:70.

AVC | Critically appraised articles

Li ZK, Nie JJ, Li J, Zhuang H. The effect of HLA on immunological response to hepatitis B vaccine in healthy people: A meta-analysis. Vaccine. 2013;31:4355-61.
Reviewers: Ortega Páez E1, Molina Arias M2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 06/10/2013
Acceptance date: 17/10/2013
Publication date: 27/11/2013

How to cite this article

Ortega Páez E, Molina Arias M. La respuesta a la vacunación de la hepatitis B puede estar condicionada por el sistema HLA. Evid Pediatr. 2013;9:70.

References

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27/11/2013

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