December 2014. Volume 10. Number 4

Does vaccination of pregnant women against pertussis protect their infants?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA. 2014;311:1760-9.

Reviewers: Llerena Santa Cruz E1, Aizpurua Galdeano P2.
1Servicio de Pediatría. Hospital Universitario Sant Joan de Dèu. Barcelona. España.
2CS Amara Berri. San Sebastián. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 28/10/2014
Acceptance date: 11/11/2014
Publication date: 26/11/2014

Abstract

Authors’ conclusions: this preliminary assessment did not find an increased risk of adverse events among women who received Tdap vaccine during pregnancy or their infants. For secondary outcomes, maternal immunization with Tdap resulted in high concentrations of pertussis antibodies in infants during the first two months of life and did not substantially alter infant responses to DTaP.

Reviewers’ commentary: this study is the first clinical trial that confirms the safety of Tdap vaccine in pregnant women and their children. Its results corroborate those of previously published retrospective studies. However, further research is needed to assess definitely whether this strategy to protect the newborn by vaccinating the mother is easy to implement and is safe and effective.

How to cite this article

Llerena Santa Cruz E, Aizpurua Galdeano P. ¿Protege al lactante la vacunación de la embarazada frente a la tos ferina? Evid Pediatr. 2014;10:73.

AVC | Critically appraised articles

Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA. 2014;311:1760-9.

Reviewers: Llerena Santa Cruz E1, Aizpurua Galdeano P2.
1Servicio de Pediatría. Hospital Universitario Sant Joan de Dèu. Barcelona. España.
2CS Amara Berri. San Sebastián. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 28/10/2014
Acceptance date: 11/11/2014
Publication date: 26/11/2014

How to cite this article

Llerena Santa Cruz E, Aizpurua Galdeano P. ¿Protege al lactante la vacunación de la embarazada frente a la tos ferina? Evid Pediatr. 2014;10:73.

References

  1. Campins M, Moreno-Pérez D, Gil-de Miguel A, González-Romo F, Moraga-Llop FA, Arístegui-Fernández J, et al. Whooping cough in Spain. Current epidemiology, prevention and control strategies. Recommendations by the Pertussis Working Group. Enferm Infecc Microbiol Clin. 2013;31:240-53.
  2. Ruiz-Canela J, Aizpurua P. ¿En una epidemia de tos ferina es útil la estrategia del Nido? Evid Pediatr. 2013;9:3.
  3. Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet. 2014;384:1521-8.
  4. Zheteyeva YA, Moro PL, Tepper NK, Rasmussen SA, Barash FE, Revzina NV, et al. Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women. Am J Obstet Gynecol. 2012;207:59.e1-7.
  5. Bechini A, Tiscione E, Boccalini S, Levi M, Bonanni P. Acellular pertussis vaccine use in risk groups (adolescents, pregnant women, newborns and health care workers): a review of evidences and recommendations. Vaccine. 2012;30:5179-90.
26/11/2014

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