December 2014. Volume 10. Number 4

Coeliac disease: the possibility of primary prevention vanishes

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med. 2014;371:1304-15.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 03/10/2014
Acceptance date: 16/10/2014
Publication date: 29/10/2014

Abstract

Authors' conclusions: the introduction of small quantities of gluten between fourth and sixth months of age doesn’t reduce the risk of celiac disease at three years of age.

Reviewers' commentary: there is a lack of solid evidence to give recommendations about the age of gluten introduction, although it seems reasonable not to introduce it before the fourth month and not to delay it after the sixth month of age. Whenever possible it should be desirable to maintain breastfeeding.

How to cite this article

Molina Arias M, Ortega Páez E. Enfermedad celiaca: se desvanece la posibilidad de realizar prevención primaria. Evid Pediatr. 2014;10:68.

AVC | Critically appraised articles

Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med. 2014;371:1304-15.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 03/10/2014
Acceptance date: 16/10/2014
Publication date: 29/10/2014

How to cite this article

Molina Arias M, Ortega Páez E. Enfermedad celiaca: se desvanece la posibilidad de realizar prevención primaria. Evid Pediatr. 2014;10:68.

References

  1. Esch CE, Rosén A, Auricchio R, Romanos J, Chmielewska A, Putter H, et al. The PreventCD study design: towards new strategies for the prevention of coeliac disease. Eur J Gastroenterol Hepatol. 2010;22:1424-30.
  2. Ivarsson A, Persson LA, Nystrom L, Ascher H, Cavell B, Danielsson L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 2000;89:165-71.
  3. Akobeng AK, Ramanan AV, Buchan I, Heller RF. Effect of breast feeding on risk of coeliac disease: a systhematic review and meta-analysis of observational studies. Arch Dis Child. 2006;91:39-43.
  4. Olsson C, Hernell O, Hornell A, Lonnberg G, Ivarsson A. Difference in celiac disease risk between Swedish birth cohorts suggest an opportunity for primary prevention. Pediatrics. 2008;122:528-34.
  5. Stordal K, White RA, Eggsbo M. Early feeding and risk of coeliac disease in a prospective birth cohort. Pediatrics. 2013;132:e1202.

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Martínez-Ojinaga Nodal E. Gluten y lactancia materna: adiós a la ventana inmunológica. Evid Pediatr. 2014;10:58.
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