June 2016. Volume 12. Number 2

Surfactant in extremely preterm infants: is it better via a thin catheter?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Kribs A, Roll C, Göpel W, Wieg C, Groneck P, Laux, et al. Nonintubated surfactant application vs conventional therapy in extremely preterm infants: a randomized clinical trial. JAMA Pediatr. 2015:169:723-30.
Reviewers: de Lucas García N1, Martín-Crespo Blanco C2.
1SAMUR-Protección Civil. Madrid. España.
2Hospital Universitario Infantil Niño Jesús. Madrid. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 18/03/2016
Acceptance date: 22/03/2016
Publication date: 30/03/2016

Abstract

Authors’ conclusions: a protocol using a less invasive surfactant application did not increase survival without bronchopulmonary dysplasia, but was associated with increased survival without major complications. Because major complications are related to lifelong disabilities, LISA may be a promising therapy for extremely preterm infants.

Reviewers’ commentary: surfactant via a thin endotracheal catheter, during CPAP-assisted spontaneous breathing in extremely preterm infants with respiratory distress syndrome is feasible, has no significant side effects and does not increase costs, achieving, besides that, a decrease in those cost associated with mechanical ventilation.

How to cite this article

De Lucas García N, Martín-Crespo Blanco MC. Surfactante en grandes prematuros: ¿mejor con sonda? Evid Pediatr. 2016;12:25.

AVC | Critically appraised articles

Kribs A, Roll C, Göpel W, Wieg C, Groneck P, Laux, et al. Nonintubated surfactant application vs conventional therapy in extremely preterm infants: a randomized clinical trial. JAMA Pediatr. 2015:169:723-30.
Reviewers: de Lucas García N1, Martín-Crespo Blanco C2.
1SAMUR-Protección Civil. Madrid. España.
2Hospital Universitario Infantil Niño Jesús. Madrid. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 18/03/2016
Acceptance date: 22/03/2016
Publication date: 30/03/2016

How to cite this article

De Lucas García N, Martín-Crespo Blanco MC. Surfactante en grandes prematuros: ¿mejor con sonda? Evid Pediatr. 2016;12:25.

References

  1. Göpel W, Kribs A, Ziegler A, Laux R, Hoehn T, Wieg C, Siegel J, Avenarius S, von der Wense A, Vochem M, et al. Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial. Lancet. 2011;5:1627-34.
30/03/2016

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