March 2016. Volume 12. Number 1

Azitromicina para el tratamiento de episodios agudos recurrentes del tracto respiratorio inferior en niños pequeños: sin pruebas concluyentes

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Pedersen TM, VindingRK, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomized, double-blind, placebo-controlled trial. Lancet Respir Med. 2016;4:19-26.
Reviewer: Buñuel Álvarez JC1.
1CS Villamayor de Gállego. Zaragoza. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 02/03/2016
Acceptance date: 04/03/2016
Publication date: 09/03/2016

Abstract

Authors’ conclusions: azithromycin reduces the duration of episodes of asthma-like symptoms (ALS) in young children, suggesting that this drug could have a role in acute management of acute exacerbation.

Reviewers’ comments: the results of this study do not allow us to establish any indication for treatment of ALSs with azithromycin. The very imprecise definition of the concept “ALS” itself, that probably correspond to heterogeneous situations, prevents us to properly identify, in these clinical settings of acute exacerbation of recurrent wheezing, potential specific clinical cases in specific groups of young patients, that could really benefit from the use of azithromycin.

How to cite this article

Buñuel Álvarez JC. Azitromicina para el tratamiento de episodios agudos recurrentes del tracto respiratorio inferior en niños pequeños: sin pruebas concluyentes. Evid Pediatr. 2016;12:13.

AVC | Critically appraised articles

Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Pedersen TM, VindingRK, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomized, double-blind, placebo-controlled trial. Lancet Respir Med. 2016;4:19-26.
Reviewer: Buñuel Álvarez JC1.
1CS Villamayor de Gállego. Zaragoza. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 02/03/2016
Acceptance date: 04/03/2016
Publication date: 09/03/2016

How to cite this article

Buñuel Álvarez JC. Azitromicina para el tratamiento de episodios agudos recurrentes del tracto respiratorio inferior en niños pequeños: sin pruebas concluyentes. Evid Pediatr. 2016;12:13.

References

  1. Bisgaard H, Hermansen MN, Bønnelykke K, Stokholm J, Baty F, Skytt NL, et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ. 2010;341:c4978.
  2. Beigelman A, Isaacson-Schmid M, Sajol G, Baty J, Rodríguez OM, Leege E, et al. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy ClinImmunol. 2015;135:1171-8.
  3. Buñuel Álvarez JC. No existen pruebas suficientes que recomienden la azitromicina para prevenir episodios de sibilancias recurrentes posbronquiolitis. Evid Pediatr. 2015;11:48.
  4. Onakpoya IJ, Hayward G, Heneghan CJ. Antibiotics for preventing lower respiratory tract infections in high-risk children aged 12 years and under. Cochrane Database Syst Rev. 2015;9:CD011530.

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