June 2023. Volume 19. Number 2

Celiac diagnosis: biopsy seems necessary if there is IgA deficiency

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Donat E, Roca M, Castillejo G, Sánchez-Valverde F, García-Burriel JI, Martínez-Ojinaga E, et al; Coeliac Disease Working Group of the Spanish Gastroenterology, Hepatology, Paediatric Nutrition Society (SEGHNP). Correlation of anti-tissue transglutaminase antibodies with the mucosal changes and IgA status of children with celiac disease. J Pediatr Gastroenterol Nutr. 2022;75:743-8.

Reviewers: Flores Villar S1, Molina Arias M2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 28/03/2023
Acceptance date: 04/04/2023
Publication date: 12/04/2023

Abstract

Authors´ conclusions: there is a positive correlation between anti-transglutaminase IgA levels and the severity of intestinal mucosal changes in celiac patients. This correlation is not observed in patients with IgA deficiency who have elevated IgG antibodies. This supports the current recommendation to perform an intestinal biopsy in individuals with IgA deficiency despite high levels of anti-transglutaminase type IgG.

Reviewers´ commentary: although the study methodology does not allow assessing the capacity of anti-transglutaminase IgA antibodies for the diagnosis of celiac disease, it does support the current recommendations of always performing a biopsy in patients with IgA deficiency and suspicion of celiac disease.

How to cite this article

Flores Villar S, Molina Arias M. Diagnóstico de enfermedad celiaca: la biopsia parece necesaria si existe déficit de IgA. Evid Pediatr. 2023;19:15.

AVC | Critically appraised articles

Donat E, Roca M, Castillejo G, Sánchez-Valverde F, García-Burriel JI, Martínez-Ojinaga E, et al; Coeliac Disease Working Group of the Spanish Gastroenterology, Hepatology, Paediatric Nutrition Society (SEGHNP). Correlation of anti-tissue transglutaminase antibodies with the mucosal changes and IgA status of children with celiac disease. J Pediatr Gastroenterol Nutr. 2022;75:743-8.

Reviewers: Flores Villar S1, Molina Arias M2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 28/03/2023
Acceptance date: 04/04/2023
Publication date: 12/04/2023

How to cite this article

Flores Villar S, Molina Arias M. Diagnóstico de enfermedad celiaca: la biopsia parece necesaria si existe déficit de IgA. Evid Pediatr. 2023;19:15.


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Linked Comment

CA | Diagnóstico de enfermedad celiaca en el déficit de IgA

Martínez-Ojinaga Nodal E. Diagnóstico de enfermedad celiaca en el déficit de IgA. Evid Pediatr. 2023;19:21.