December 2010. Volume 6. Number 4

Vaccine RTS,S/SA01E, a step in the pursuit of routine vaccination against malaria

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Agnandji ST, Asante KP, Lyimo J, Vekemans J, Soulanoudjingar SS, Owusu R, et al. Evaluation of the safety and immunogenicity of the RTS,S/AS01E malaria candidate vaccine when integrated in the expanded program of immunization. J Infect Dis. 2010;202:1076-87.
Reviewers: Fernández Rodríguez M1, Orejón de Luna G2.
1Centro de Salud de Potes. Madrid. España.
2CS General Ricardos. Madrid. España.
Correspondence: Mercedes Fernández Rodríguez. Email: mer763@hotmail.com
Reception date: 18/10/2010
Acceptance date: 17/11/2010
Publication date: 25/11/2010

Abstract

Authors´ conclusions: RTS,S/ASO1E, malaria candidate vacccine integrated in the expanded program of immunization (EPI), showed a favorable safety and immnogenicity evaluation.

Reviewers´ commentary: RTS,S/ASO1E, malaria candidate vacccine does not compromise the immunogenicity of other systematic vaccines and it does not show significant adverse events. It is necessary to determine its efectiveness and its medium-term protection.

How to cite this article

Fernández Rodriguez M, Orejón de Luna G. La vacuna RTS,S/SA01E, un paso más en la búsqueda de la vacunación sistemática frente a la malaria. Evid Pediatr. 2010;6:90.

AVC | Critically appraised articles

Agnandji ST, Asante KP, Lyimo J, Vekemans J, Soulanoudjingar SS, Owusu R, et al. Evaluation of the safety and immunogenicity of the RTS,S/AS01E malaria candidate vaccine when integrated in the expanded program of immunization. J Infect Dis. 2010;202:1076-87.
Reviewers: Fernández Rodríguez M1, Orejón de Luna G2.
1Centro de Salud de Potes. Madrid. España.
2CS General Ricardos. Madrid. España.
Correspondence: Mercedes Fernández Rodríguez. Email: mer763@hotmail.com
Reception date: 18/10/2010
Acceptance date: 17/11/2010
Publication date: 25/11/2010

How to cite this article

Fernández Rodriguez M, Orejón de Luna G. La vacuna RTS,S/SA01E, un paso más en la búsqueda de la vacunación sistemática frente a la malaria. Evid Pediatr. 2010;6:90.

References

  1. MS. Estadísticas sanitarias mundiales 2010 [en línea] [fecha de consulta: 8-X-2010]. Disponible en: http://www.who.int/whosis/whostat/ES_WHS10_Full.pdf
  2. González de Dios J, Perdikidis L. Prometedores resultados en la investigación sobre vacuna de la malaria: eficaz y segura no solo en niños, sino también en lactantes. Evid Pediatr. 2008;4:7
  3. Orejón de Luna G, Ramos Lizana J. Una vacuna eficaz frente a la malaria podría ser incluida en los calendarios vacunales infantiles, sin interferir con la respuesta inmunológica al resto de antígenos. Evid Pediatr. 2009;5:7.  
  4. Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, OwusuR, Ayiwa Wireko Brobby N, et al. Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria candidate vaccines given according to different schedules in Ghanaian children. Plos One. 2009;4:e7302.
  5. Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J, et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Med. 2008;359:2521-32.
25/11/2010

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