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Evidencias en Pediatría (EP / Evidences in Pediatrics) is a publication of the “Asociación Española de Pediatría” (AEP / Spanish Association of Pediatrics). Its contents are elaborated mainly by members of the Grupo de Trabajo de Pediatría Basada en la Evidencia (Evidence Based Pediatrics Working Group). This group is part of both, the AEP and the “Asociación Española de Pediatría de Atención Primaria” (Spanish Association of Primary Care Pediatrics / AEPap).
Authors’ conclusions: the reviewed studies show discrepancies on cranberry juice efficacy on urinary tract infections’ recurrence in children. One study finds no difference between cranberry juice and prophylactic antibiotics. No relevant adverse effects were found, although there were some drop outs due to its flavour.
Reviewers’ commentary: the best conducted study finds a slight efficacy of cranberry juice on reducing the overall number of urinary tract infections in the sample but not in the number of children with recurrences. The other two studies have methodological problems that rise doubts on the validity of their results. The product seems innocuous.
Esparza Olcina MJ, Benito Herreros AM. Los preparados de arándano, inocuos pero de dudosa eficacia para la infección urinaria en niños. Evid Pediatr. 2012;8:30.
Salo J, Uhari M, Helminen M, Korppi M, Nieminen T, Pokka T et al. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis. 2012;54:340-6. http://www.ncbi.nlm.nih.gov/pubmed/22100577
Nishizaki N, Someya T, Hirano D, Fujinaga S, Ohtomo Y, Shimizu T et al. Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux? Pediatr Int. 2009;51:433-4. http://www.ncbi.nlm.nih.gov/pubmed/19438835
Ferrara P, Romanello L, Vitelli O, Gatto A, Serva M, Cataldi L. Cranberry juice for the prevention of recurrent urinary tract infections: A randomized controlled trial in children. Scand J Urol Nephrol. 2009;43:369-72. http://www.ncbi.nlm.nih.gov/pubmed/19921981
Ochoa Sangrador C, Málaga Guerrero S. Panel de Expertos de la Conferencia de Consenso; Grupo Investigador de la Conferencia de Consenso. Recomendaciones de la Conferencia de Consenso ''Manejo Diagnóstico y Terapéutico de las Infecciones del Tracto Urinario en la Infancia''. An Pediatr (Barc). 2007;67:517-25. http://www.ncbi.nlm.nih.gov/pubmed/17991371