Authors’ conclusions: although L. reuteri may be effective as a treatment strategy for crying in exclusively breastfed infants with colic, the evidence supporting probiotic use for the treatment of infant colic or crying in formula-fed infants remains unresolved. Results from larger rigorously designed studies will help draw more definitive conclusions.
Reviewers’ commentary: L reuteri is useful in reducing the time of infant crying. It reduces an average of 55 minutes per day, but only in mothers with exclusive breastfeeding and milk protein-free diet. It is still premature to generalize these results, and it is not known if this strain will work in different populations, or if it is cost-effective to give this treatment for 21 days.