June 2018. Volume 14. Number 1

Intramuscular ACTH is not superior to oral prednisolone in the control of spasms in West syndrome

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wanigasinghe J, Arambepola C, Ranganathan SS, Sumanasena S. Randomized, single-blind, parallel clinical trial on efficacy of oral prednisolone versus intramuscular corticotropin: a 12-month assessment of spasm control in west syndrome. Pediatr Neurol. 2017;76:14-19.

Reviewers: Rivero Martín MJ1, Cuestas Montañés E2.
1Departamento de Medicina. Universidad Rey Juan Carlos. Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Madrid. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 25/06/2018
Acceptance date: 28/06/2018
Publication date: 04/07/2018

Abstract

Authors’ conclusions: control of spasms at three months was significantly better if initially treated with prednisolone. Control of spasms at six and 12 months was not significantly different despite a trend favoring prednisolone. Risk of relapse following initial remission was similar in the two groups.

Reviewers’ commentary: oral prednisolone versus intramuscular ACTH is equally effective for the control of spasms in West syndrome, being a more accessible medication that can be administered by caregivers. In addition, the treatment costs are lower without increasing side effects.

How to cite this article

Rivero Martín MJ, Cuestas Montañes E. La ACTH intramuscular no es superior a prednisolona oral en el tratamiento de los espasmos del síndrome de West. Evid Ped. 2018;14:5.

AVC | Critically appraised articles

Wanigasinghe J, Arambepola C, Ranganathan SS, Sumanasena S. Randomized, single-blind, parallel clinical trial on efficacy of oral prednisolone versus intramuscular corticotropin: a 12-month assessment of spasm control in west syndrome. Pediatr Neurol. 2017;76:14-19.

Reviewers: Rivero Martín MJ1, Cuestas Montañés E2.
1Departamento de Medicina. Universidad Rey Juan Carlos. Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Madrid. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 25/06/2018
Acceptance date: 28/06/2018
Publication date: 04/07/2018

How to cite this article

Rivero Martín MJ, Cuestas Montañes E. La ACTH intramuscular no es superior a prednisolona oral en el tratamiento de los espasmos del síndrome de West. Evid Ped. 2018;14:5.

04/07/2018

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