Authors´ conclusions: the findings of the study show that at three months of age, most children did not have protective titers of antibody against measles. These findings have important implications for general immunization and post-exposure recommendations, since until now, it was considered that up to six months of age there was immunity for measles. Additional studies are needed to prospectively validate these data and to explore the impact on that of maternal age and breastfeeding.
Reviewers´ commentary: according to the data of the study, immunity against measles in infants, acquired from their mothers, decreases significantly after three months and is practically non-existent at six months of age. These data could justify the advancement in the administration of the first dose of the MMR vaccine before one year of age, but before that it would be necessary to carry out immunity and tolerance studies and determine the ideal age for it.