September 2025. Volume 21. Number 3

Should we use continuous infusion of vancomycin in neonatal sepsis caused by coagulase-negative staphylococcus?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Gérard R, Pauquet E, Ros B, Lehours P, Renesme l. Continuous Versus Intermittent Vancomycin Infusions for Coagulase-negative Staphylococcus Bacteremia in Neonates: A Propensity-matched Cohort Study. Pediatr Infect Dis J. 2025.1;44:131-5.

Reviewers: Pérez-Moneo Agapito B1, Aparicio Sánchez JL2.
1Servicio de Pediatría. Hospital Universitario Infanta Leonor. Universidad Complutense. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: Begoña Pérez-Moneo Agapito. Email: begopma@gmail.com
Reception date: 25/08/2025
Acceptance date: 01/09/2025
Publication date: 17/09/2025

Abstract

Authors’ conclusions: in neonates with coagulase-negative staphylococcus bacteremia, continuous vancomycin infusion, compared to intermittent dosing, was associated with a lower rate of therapeutic failure and a shorter time to reach therapeutic levels, without increasing renal toxicity.

Reviewers’ comments: continuous vancomycin infusion is feasible in NICUs with adequate resources. Preterm neonates with coagulase-negative staphylococcus sepsis and vascular access would be ideal candidates. Although promising, its implementation as a standard of care requires further evidence, ideally from multicenter randomized clinical trials.

How to cite this article

Pérez-Moneo Agapito B, Aparicio Sánchez JL. ¿Debemos usar vancomicina en infusión continua en la sepsis neonatal por estafilococo coagulasa negativo? Evid Pediatr. 2025;21:33.

AVC | Critically appraised articles

Gérard R, Pauquet E, Ros B, Lehours P, Renesme l. Continuous Versus Intermittent Vancomycin Infusions for Coagulase-negative Staphylococcus Bacteremia in Neonates: A Propensity-matched Cohort Study. Pediatr Infect Dis J. 2025.1;44:131-5.

Reviewers: Pérez-Moneo Agapito B1, Aparicio Sánchez JL2.
1Servicio de Pediatría. Hospital Universitario Infanta Leonor. Universidad Complutense. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: Begoña Pérez-Moneo Agapito. Email: begopma@gmail.com
Reception date: 25/08/2025
Acceptance date: 01/09/2025
Publication date: 17/09/2025

How to cite this article

Pérez-Moneo Agapito B, Aparicio Sánchez JL. ¿Debemos usar vancomicina en infusión continua en la sepsis neonatal por estafilococo coagulasa negativo? Evid Pediatr. 2025;21:33.


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AM | Índices de propensión

Pérez-Moneo Agapito B, Aparicio Sánchez JL. Índices de propensión. Evid Pediatr. 2025;21:39.
17/09/2025

Linked Comment

Methodological note

AM | Índices de propensión

Pérez-Moneo Agapito B, Aparicio Sánchez JL. Índices de propensión. Evid Pediatr. 2025;21:39.