June 2006. Volume 2. Number 2

In hospitalized febrile children a single oral dose of ibuprofen followed by a single oral dose of acetaminophen four hours later had larger reduction in their body temperatures at 6 and 8 hours from baseline with no definite conclusions on the safety of

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Nabulsi MM, Tamiz H, Mahfoud Z, Itani M, Sabra R, Chamseddine F, et al. Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061]. BMC Medicine. 2006;4:4
Reviewers: Buñuel Álvarez JC1, Cortés Marina RB2.
1 ABS Girona-4 (Institut Catalá de la Salut). Girona. España.
2 ABS Girona-3 Montilivi. Institut Catalá de la Salut. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: p416ucua@pgirona.scs.es
Reception date: 05/05/2006
Acceptance date: 09/05/2006
Publication date: 01/06/2006

Abstract

How to cite this article

Buñuel Álvarez JC, Cortés Marina RB. En niños ingresados con fiebre y tratados con una dosis de ibuprofeno, la administración de paracetamol 4 horas después reduce la presencia de fiebre a las 6-8 horas, sin poder determinarse la seguridad de dicha intervención. Evid Pediatr. 2006;2:19.

AVC | Critically appraised articles

Nabulsi MM, Tamiz H, Mahfoud Z, Itani M, Sabra R, Chamseddine F, et al. Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061]. BMC Medicine. 2006;4:4
Reviewers: Buñuel Álvarez JC1, Cortés Marina RB2.
1 ABS Girona-4 (Institut Catalá de la Salut). Girona. España.
2 ABS Girona-3 Montilivi. Institut Catalá de la Salut. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: p416ucua@pgirona.scs.es
Reception date: 05/05/2006
Acceptance date: 09/05/2006
Publication date: 01/06/2006

How to cite this article

Buñuel Álvarez JC, Cortés Marina RB. En niños ingresados con fiebre y tratados con una dosis de ibuprofeno, la administración de paracetamol 4 horas después reduce la presencia de fiebre a las 6-8 horas, sin poder determinarse la seguridad de dicha intervención. Evid Pediatr. 2006;2:19.

References

  1. Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004; 158:521-6.
  2. Mayoral CE, Marino RV, Rosenfeld W, Greensher J. Alternating antipyretics: is this an alternative? Pediatrics. 2000; 105:1009-12.
  3. Sarrell EM, Wielunsky E, Cohen AH. Antipyretic treatment in young children with fever. Acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. Arch Pediatr Adolesc Med. 2006;160:197-202.
  4. Erlewyn MDS, Coppens K, Hunt LP, Chinnick PJ, Davies P, Higginson IM, et al. Randomised controlled trial of combined paracetamol and ibuprofen for fever. Arch Dis Child. 2006;91:414-6.
  5. Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics. 1999;104:e39.
01/06/2006

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