October 2008. Volume 4. Number 3

La hipotermia no mejora la evolución del traumatismo craneoencefálico grave pediátrico

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Hutchinson JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ et al. Hypothermia therapy after traumatic brain injury in children. N Engl Med. 2008.358:2447-56
Reviewers: Modesto i Alapont V1, Aparicio Rodrigo M2.
1 Unidad de Cuidados Intensivos Pediátricos. Hospital Infantil La Fe. Valencia. España.
2 Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Vicent Modesto i Alapont. Email: vicibego@telefonica.net
Reception date: 7/08/2008
Acceptance date: 09/08/2008
Publication date: 01/09/2008

Abstract

Authors’s conclusions: In children with severe traumatic brain injury, hypothermia therapy started within eight hours after injury and continued for 24 hours does not improve neurological outcome six months later, and also may increase mortality.

Reviewer’s commentary: Traumatic brain injury is a frequent cause of death and brain damage in Childhood. The efficacy of hypothermia for the treatment of hypoxic-ischemic encephalopathy both in adult and neonates, has suggested that it could be useful for traumatic brain injury. This study shows that the early application of this procedure doesn't prevent brain damage and could be harmful. Therefore its use in the paediatric intensive care units is discouraged in these cases.

How to cite this article

Modesto i Alapont V, Aparicio Rodrigo M. La hipotermia no mejora la evolución del traumatismo craneoencefálico grave pediátrico. Evid Pediatr. 2008;4:56.

AVC | Critically appraised articles

Hutchinson JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ et al. Hypothermia therapy after traumatic brain injury in children. N Engl Med. 2008.358:2447-56
Reviewers: Modesto i Alapont V1, Aparicio Rodrigo M2.
1 Unidad de Cuidados Intensivos Pediátricos. Hospital Infantil La Fe. Valencia. España.
2 Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Vicent Modesto i Alapont. Email: vicibego@telefonica.net
Reception date: 7/08/2008
Acceptance date: 09/08/2008
Publication date: 01/09/2008

How to cite this article

Modesto i Alapont V, Aparicio Rodrigo M. La hipotermia no mejora la evolución del traumatismo craneoencefálico grave pediátrico. Evid Pediatr. 2008;4:56.

References

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  3. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663-70.
  4. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574-84.
  5. Alderson P, Gadkary C, Signorini DF. Hipotermia terapéutica para el traumatismo de cráneo (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com. (Traducida de The Cochrane Library, 2008 Issue 2. Chichester, UK: John Wiley & Sons, Ltd.).
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  7. Adelson PD, Ragheb J, Kanev P, Brockmeyer D, Beers SR, Brown SD et al. Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery. 2005;56:740-54.
01/09/2008

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