September 2013. Volume 9. Number 3

Do serum alanine aminotransferase levels predict cardiovascular risk in children and adolescents?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Healthy range of serum alanine aminotransferase and its predictive power for cardiovascular risk in children and adolescents. JPGN.2013;56:686-91.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología y Nutrición. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 18/07/2013
Acceptance date: 22/07/2013
Publication date: 31/07/2013

Abstract

Author's conclusions: reference values for Korean children and adolescents and shows that, in a nationally representative population, alanine aminotransferase levels greater than the upper normal limit predict the existence of cardiovascular risk factors.

Reviewers' commentary: it is necessary to accurately determine the relationship between alanine aminotransferase levels and metabolic syndrome in our population before we can safely recommend it as a surrogate marker of cardiovascular risk.


How to cite this article

Molina Arias M, Ortega Páez E. ¿Predicen los niveles de alanina aminotransferasa en suero el riesgo cardiovascular en niños y adolescentes? Evid Pediatr.2013;9:48.

AVC | Critically appraised articles

Healthy range of serum alanine aminotransferase and its predictive power for cardiovascular risk in children and adolescents. JPGN.2013;56:686-91.
Reviewers: Molina Arias M1, Ortega Páez E2.
1Servicio de Gastroenterología y Nutrición. Hospital Infantil Universitario La Paz. Madrid. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 18/07/2013
Acceptance date: 22/07/2013
Publication date: 31/07/2013

How to cite this article

Molina Arias M, Ortega Páez E. ¿Predicen los niveles de alanina aminotransferasa en suero el riesgo cardiovascular en niños y adolescentes? Evid Pediatr.2013;9:48.

References

  1. Yun JE, Kim SY, Kang HC, Lee SJ, Kimm H, Jee SH. Alanine aminotransferase is associated with metabolic syndrome independently of insulin resistance. Circ J.2011;75:964-9.
  2. Patel DA, Srinivasan SR, Chen W. Serum alanine aminotransferase and its association with metabolic syndrome in children: the Bogalusa Heart study. Metab Syndr Relat Disord.2011;9:211-6.
  3. Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolecents and associated factors: NHANES 1999-2004. Gastroenterology.2007;133:1814-20.
  4. Bethel MA, Deedwania P, Levitt NS, Schmitz O, Huntsman-Labed A, Califf RM et al. Metabolic syndrome and alanine aminotransferase: a global perspective from the NAVIGATOR screening population. Diabet Med.2009;26:1204-11.
31/07/2013

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