June 2015. Volume 11. Number 2

Measles-mumps-rubella-varicella vaccine produces more febrile seizures than the separated vaccines

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

MacDonald SE, Dover DC, Simmonds KA, Svenson LW. Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study. CMAJ. 2014;186:824-9.
Reviewers: Esparza Olcina MJ1, García Vera C2.
1Centro de Salud Barcelona. Móstoles. Madrid. España.
2CS Sagasta-Ruiseñores. Zaragoza. España.
Correspondence: María Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 06/09/2014
Acceptance date: 31/10/2014
Publication date: 20/05/2015

Abstract

Authors’ conclusions: measles-mumps-rubella-varicella (MMRV) vaccine increases the risk of febrile seizures comparing to separated measles-mumps-rubella and varicella. Nevertheless the absolute risk is small, so that vaccination policy makers should take into consideration the risks and benefits of this formulation.

Reviewers’ commentary: in agreement with previous studies, it appears that the first shot of MMRV in the second year of life is related to a higher risk of febrile seizures than the separated MMR and varicella vaccines. In view of the fact that the absolute risk is one more febrile seizure every 2841 administered doses, it is mandatory to consider its pros and cons.

How to cite this article

Esparza Olcina MJ, Garcia Vera C. La vacuna tetravírica (triple vírica y varicela) produce más convulsiones febriles que la vacunación por separado. Evid Pediatr. 2015;11:23.

AVC | Critically appraised articles

MacDonald SE, Dover DC, Simmonds KA, Svenson LW. Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study. CMAJ. 2014;186:824-9.
Reviewers: Esparza Olcina MJ1, García Vera C2.
1Centro de Salud Barcelona. Móstoles. Madrid. España.
2CS Sagasta-Ruiseñores. Zaragoza. España.
Correspondence: María Jesús Esparza Olcina. Email: mjesparza8@gmail.com
Reception date: 06/09/2014
Acceptance date: 31/10/2014
Publication date: 20/05/2015

How to cite this article

Esparza Olcina MJ, Garcia Vera C. La vacuna tetravírica (triple vírica y varicela) produce más convulsiones febriles que la vacunación por separado. Evid Pediatr. 2015;11:23.

References

  1. García Vera C, Aizpurua Galdeano P. La vacuna cuádruple vírica (sarampión-rubéola-parotiditis-varicela) podría duplicar la incidencia de convulsiones febriles en comparación con la administración separada de las vacunas triple vírica y varicela. Evid Pediatr. 2010;6:82.
  2. Klein NP, Fireman B, Yih WK, Lewis E, Kulldorff M, Ray P, et al; Vaccine Safety Datalink. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics. 2010;126:e1-8.
  3. Klein NP, Lewis E, Baxter R, Weintraub E, Glanz J, Naleway A, et al. Measles-containing vaccines and febrile seizures in children age 4 to 6 years. Pediatrics. 2012;129:809-14.
  4. Schink T, Holstiege J, Kowalzik F, Zepp F, Garbe E. Risk of febrile convulsions after MMRV vaccination in comparison to MMR or MMR+V vaccination. Vaccine. 2014;32:645-50.
  5. Ochoa Sangrador C, Orejón de Luna G. La vacuna combinada frente a sarampión, parotiditis, rubéola y varicela presenta una inmunogenicidad similar a las vacunas triple vírica y varicela administradas por separado, a expensas de un gran aumento de la carga de virus varicela atenuado en la vacuna tetravalente. Evid Pediatr. 2006;2:3.
20/05/2015

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