March 2015. Volume 11. Number 1

Maternal supplementation with folic acid during pregnancy slightly reduces the risk of acute leukemia in offspring

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Metayer C, Milne E, Dockerty JD, Clavel J, Pombo-de-Oliveira MS, Wesseling C, et al. Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring. A Childhood Leukemia International Consortium study. Epidemiology. 2014;25:811-22.
Reviewers: Ortega Páez E1, Molina Arias M2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 23/02/2015
Acceptance date: 03/03/2015
Publication date: 11/03/2015

Abstract

Authors' conclusions:maternal prenatal use of vitamins and folic acid reduces the risk of both acute lymphoblastic and acute myeloid leukemia in children. This association varies by parental education, a surrogate for lifestyle and sociodemographic characteristics.

Reviewers' commentary: data heterogeneity and potential bias compromise the internal validity of the study. This and the limitations of its observational design make it advisable further studies with highest level of evidence in order to systematically recommend folic acid and vitamins supplementation to all women of childbearing age one year before and during pregnancy.

How to cite this article

Ortega Páez E, Molina Arias M. La suplementación con ácido fólico durante el embarazo reduce levemente el riesgo de leucemia aguda en el niño. Evid Pediatr. 2015;11:14.

AVC | Critically appraised articles

Metayer C, Milne E, Dockerty JD, Clavel J, Pombo-de-Oliveira MS, Wesseling C, et al. Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring. A Childhood Leukemia International Consortium study. Epidemiology. 2014;25:811-22.
Reviewers: Ortega Páez E1, Molina Arias M2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 23/02/2015
Acceptance date: 03/03/2015
Publication date: 11/03/2015

How to cite this article

Ortega Páez E, Molina Arias M. La suplementación con ácido fólico durante el embarazo reduce levemente el riesgo de leucemia aguda en el niño. Evid Pediatr. 2015;11:14.

References

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  2. Goh Yi, Koren G. Folic acid in pregnancy and fetal outcomes. J Obstet Gynaecol. 2008;28:3-13.
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  4. Proyección de la Población de España 2014-2064. Notas de prensa. En: Instituto Nacional de Estadística [en línea] [consultado el 03/03/15]. Disponible en: http://www.ine.es/prensa/np870.pdf
  5. Dockerty JD, Herbison P, Skegg DC, Elwood M. Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study. BMC Public Health. 2007;7:136.
  6. Thompson JR, Gerald PF, Willoughby ML, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet. 2001;358:1935-40.
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