December 2016. Volume 12. Number 4

Diagnostic test accuracy of a RNA biomarker for discriminating bacterial versus viral infection in febrile children

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, et al. Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children. JAMA. 2016;316:835-45.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1CS Virgen de África. Sevilla. España.
2CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 13/12/2016
Acceptance date: 16/12/2016
Publication date: 21/12/2016

Abstract

Authors´ conclusions: the results of the study provide preliminary data on the diagnostic accuracy of the test described for the distinction between bacterial and viral infection in children with fever

Reviewers´ commentary: this study offers preliminary data on a test using a RNA biomarker. Although it seems to differentiate between bacterial and viral infections, the available information does not allow to evaluate its clinical utility. It is necessary to demonstrate its usefulness in different scenarios, such as emergency services or primary care, and to assess its contribution in reducing the use of antibiotics with a more accurate diagnosis of bacterial infection.

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. Valor diagnóstico de un biomarcador de ARN para discriminar infección vírica o bacteriana en niños con fiebre. Evid Pediatr. 2016;12:67.

AVC | Critically appraised articles

Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, et al. Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children. JAMA. 2016;316:835-45.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1CS Virgen de África. Sevilla. España.
2CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 13/12/2016
Acceptance date: 16/12/2016
Publication date: 21/12/2016

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. Valor diagnóstico de un biomarcador de ARN para discriminar infección vírica o bacteriana en niños con fiebre. Evid Pediatr. 2016;12:67.

References

  1. Bauchner H. Genetics and the evaluation of the febrile child.JAMA. 2016;316:824-5.
  2. Nijman RG, Vergouwe Y, Thompson M, van Veen M, van Meurs AH, van der Lei J, et al. Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study. BMJ. 2013;346:f1706.
  3. Marín Reina P, Ruiz Alcántara I, Vidal Micó S, López-Prats Lucea JL, Modesto I Alapont V. Exactitud del test de procalcitonina en el diagnóstico de bacteriemia oculta en pediatría: revisión sistemática y metanálisis. An Pediatr (Barc). 2010;72:403-12.

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