December 2016. Volume 12. Number 4

Inhaled bronchodilatator via metered-dose inhaler and a spacer for acute asthma in children: searching for ideal dosage

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Muchão FP, Souza JM, Torres HC, De Lalibera IB, de Souza AV, Rodrigues JC, et al. Albuterol via metered-dose inhaler in children: lower doses are effective, and higher doses are safe. Pediatr Pulmonol. 2016;51:1122-30.
Reviewers: Gimeno Díaz de Atauri Á1, Castillo Campos L2.
1Servicio de Pediatría. Hospital 12 de Octubre. Madrid. España.
2Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agimenodatauri@gmail.com
Reception date: 02/11/2016
Acceptance date: 04/11/2016
Publication date: 09/11/2016

Abstract

Authors´ conclusions: higher albuterol dosage regimens, compared to lower ones, did not result in lower admission rate or shorter length of stay in the ER, but showed similar safety profile for children with moderate to severe acute asthma.

Reviewers´ commentary: in children with moderate or severe asthmatic exacerbations, treatment with 600 mcg of albuterol, administered with a spacer, seems to be as effective and safe as higher dosage regimens, although there could be real differences that haven’t been real differences that haven’t been found, because of lack of statistical power. It would be interesting to study if even lower doses are also effective, and if there are differences of effectiveness depending on the severity.

How to cite this article

Gimeno Díaz de Atauri A, Castillo Campos L. Broncodilatador inhalado con cámara espaciadora en las crisis asmáticas en niños: en busca de la dosis ideal. Evid Pediatr. 2016;12:63.

AVC | Critically appraised articles

Muchão FP, Souza JM, Torres HC, De Lalibera IB, de Souza AV, Rodrigues JC, et al. Albuterol via metered-dose inhaler in children: lower doses are effective, and higher doses are safe. Pediatr Pulmonol. 2016;51:1122-30.
Reviewers: Gimeno Díaz de Atauri Á1, Castillo Campos L2.
1Servicio de Pediatría. Hospital 12 de Octubre. Madrid. España.
2Servicio de Pediatría. Hospital Universitario 12 de Octubre. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agimenodatauri@gmail.com
Reception date: 02/11/2016
Acceptance date: 04/11/2016
Publication date: 09/11/2016

How to cite this article

Gimeno Díaz de Atauri A, Castillo Campos L. Broncodilatador inhalado con cámara espaciadora en las crisis asmáticas en niños: en busca de la dosis ideal. Evid Pediatr. 2016;12:63.

References

  1. Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev. 2013;(9):CD000052.
  2. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 2014;69:1-192.
  3. GEMA 4.0. Guía española para el manejo del asma [en línea] [consultado el 4/11/2016]. Disponible en: http://www.gemasma.com
  4. Benito Fernández J, Trebolazabala Quirante N, Landa Guarriz M, Mintegi Raso S, González Díaz C. Bronchodilators via metereddose inhaler with spacer in the pediatric emergency department: what is the dosage? An Pediatr (Barc). 2006;64:46-51.
09/11/2016

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