Authors' conclusions: pain was reduced when the DPTaPHib vaccine was administered before the PCV in infants undergoing routine vaccination. On the basis of these results, we recommend that the order of vaccines be the DPTaP-Hib vaccine followed by the PCV.
Reviewers' commentary: infant pain response during routine intramuscular inmunization was affected by the order of administration of the vaccines. When two vaccines are given together, the least painful should be administered first. This strategy is simple, effective, cost free, and easily incorporated into clinical practice.