September 2010. Volume 6. Number 3

Hypertrophic pyloric stenosis has strong familial aggregation and heritability

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Krogh C, Fischer TK, Skotte L, Biggar RJ, Øyen N, Skytthe A, et al. Familial aggregation and heritability of pyloric stenosis. JAMA.2010;303:2393-9
Reviewers: Aizpurua Galdeano P1, Ibáñez Pradas V2.
1ABS 7 La Salut Badalona. Badalona. España.
2 Servicio de Cirugía Pediátrica. Hospital General de Castellón. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 30/07/2010
Acceptance date: 04/08/2010
Publication date: 18/08/2010

Abstract

Authors’ conclusions: Hypertrophic pyloric stenosis in Danish children shows strong familial aggregation (relative risk in siblings is 18.5) and heritability (87%).

Reviewers’ commentary: Thanks to specific databases, familial aggregation of pyloric stenosis has been determined more accurately. The high rate ratios in relatives of probands have to be taken into account when evaluating a patient with a history of familial pyloric stenosis and vomits.

How to cite this article

Aizpurua Galdeano P, Ibáñez Pradas V. La estenosis hipertrófica del píloro es una enfermedad que se presenta con una fuerte agregación familiar y heredabilidad. Evid Pediatr. 2010;6:58.

AVC | Critically appraised articles

Krogh C, Fischer TK, Skotte L, Biggar RJ, Øyen N, Skytthe A, et al. Familial aggregation and heritability of pyloric stenosis. JAMA.2010;303:2393-9
Reviewers: Aizpurua Galdeano P1, Ibáñez Pradas V2.
1ABS 7 La Salut Badalona. Badalona. España.
2 Servicio de Cirugía Pediátrica. Hospital General de Castellón. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 30/07/2010
Acceptance date: 04/08/2010
Publication date: 18/08/2010

How to cite this article

Aizpurua Galdeano P, Ibáñez Pradas V. La estenosis hipertrófica del píloro es una enfermedad que se presenta con una fuerte agregación familiar y heredabilidad. Evid Pediatr. 2010;6:58.

References

  1. Mitchell LE, Risch N. The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. Am J Dis Child.1993;147:1203-11.
18/08/2010

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