September 2012. Volume 8. Number 3

Should we incorporate procalcitonin to the diagnosis of infants under 2 months with fever of unknown origin?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Woelker JU, Sinha M, Christopher NC, Powell KR. Serum procalcitonin concentration in the evaluation of febrile infants 2 to 60 days of age. Pediatr Emerg Care. 2012;28:410-5.
Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jmandres@ono.com
Reception date: 11/07/2012
Acceptance date: 28/08/2012
Publication date: 05/09/2012

Abstract

Authors’s conclusions: procalcitonin is an important serological marker of serious bacterial infections in infants aged 2 to 60 days. The predictive value of procalcitonin in combination with pyuria count may be clinically useful.

Reviewer’s commentary: procalcitonin improves the predictive capability of bacterial infection comparing with other clinical and laboratory parameters, although it is unclear the utility of its incorporation into clinical practice. It is necessary to evaluate its impact in clinically relevant outcomes.

How to cite this article

Ochoa Sangrador C. Andrés de Llano JM. ¿Debemos incorporar la procalcitonina al diagnóstico de lactantes menores de dos meses con fiebre sin foco? Evid Pediatr. 2012;8:53.

AVC | Critically appraised articles

Woelker JU, Sinha M, Christopher NC, Powell KR. Serum procalcitonin concentration in the evaluation of febrile infants 2 to 60 days of age. Pediatr Emerg Care. 2012;28:410-5.
Reviewers: Andrés de Llano JM1, Ochoa Sangrador C2.
1Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
2Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
Correspondence: Jesús María Andrés de Llano. Email: jmandres@ono.com
Reception date: 11/07/2012
Acceptance date: 28/08/2012
Publication date: 05/09/2012

How to cite this article

Ochoa Sangrador C. Andrés de Llano JM. ¿Debemos incorporar la procalcitonina al diagnóstico de lactantes menores de dos meses con fiebre sin foco? Evid Pediatr. 2012;8:53.

References

  1. FUS Team, Cincinnati Children's Hospital Medical Center: Evidence-based clinical care guideline for fever of uncertain source in infants 60 days of age or less, http://www.cincinnatichildrens.org/svc/alpha/h/health-policy/ev-based/default.htm. Guideline 02, pages 1-14, October 2010.
  2. Olaciregui I, Hernández U, Muñoz JA, Emparanza JI, Landa JJ. Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. Arch Dis Child. 2009;94:501-5.
  3. Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detection of serious bacterial infections. Pediatrics. 2008;122:701-10.
  4. Luaces-Cubells C, Mintegi S, García-García JJ, Astobiza E, Garrido-Romero R, Velasco-Rodríguez J, et al .Procalcitonin to detect invasive bacterial infection in non-toxic-appearing infants with fever without apparent source in the emergency department. Pediatr Infect Dis J. 2012;31:645-647.
  5. Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, Mant D. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011;342:d3082.
05/09/2012

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