June 2014. Volume 10. Number 2

The live attenuated influenza vaccine, in children less than two years of age, seems to be effective

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Prutsky GJ, Domecq JP, Elraiyah T, Prokop LJ, Murad MH. Assessing the evidence: live attenuated influenza vaccine in children younger than 2 years. A systematic review. Pediatr Infect Dis J. 2014;33:e106-15.
Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 21/04/2014
Acceptance date: 20/05/2014
Publication date: 04/06/2014

Abstract

Authors' conclusions: live attenuated influenza vaccine (LAIV) in children under two years is more effective than placebo and as effective as inactivated influenza vaccine. The safety profile of LAIV is reasonable although evidence is scarce. LAIV may be considered as an option in this age group.

Reviewers' commentary: according to the available evidence, live attenuated virus influenza vaccines could be an alternative to inactivated vaccines, as they are at least as effective as these. Doubts about the safety of these vaccines (risk of episodes of wheezing), have limited the making of clinical trials, so that the available information is scarce, but not more scarce than that available about inactivated vaccines.

How to cite this article

Ochoa Sangrador C, Andrés de Llano JM. La vacuna antigripal viva atenuada en menores de dos años parece eficaz. Evid Pediatr. 2014;10:32.

AVC | Critically appraised articles

Prutsky GJ, Domecq JP, Elraiyah T, Prokop LJ, Murad MH. Assessing the evidence: live attenuated influenza vaccine in children younger than 2 years. A systematic review. Pediatr Infect Dis J. 2014;33:e106-15.
Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 21/04/2014
Acceptance date: 20/05/2014
Publication date: 04/06/2014

How to cite this article

Ochoa Sangrador C, Andrés de Llano JM. La vacuna antigripal viva atenuada en menores de dos años parece eficaz. Evid Pediatr. 2014;10:32.

References

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  2. Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, et al.; CAIV-T Comparative Efficacy Study Group. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med. 2007;356:685-96.
  3. Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V, Ferroni E. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev. 2012;8:CD004879.
  4. Luce BR, Nichol KL, Belshe RB, Frick KD, Li SX, Boscoe A, et al. Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the  United States. Vaccine. 2008;26:2841-8.
04/06/2014

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