Authors´ conclusions: fecal calprotectin has high accuracy for diagnosis of inflammatory bowel disease (IBD) in tertiary referral centers. Both the concentration of calprotectin and the child's age are associated with the diagnosis of IBD.
Reviewers´ commentary: fecal calprotectin is a determination of high diagnostic performance in childhood inflammatory bowel disease. Its usefulness would be different according to the clinical stage. In clinical settings with a high prevalence of IBD, specific to specialized care, it would be most useful for the selection of those patients more appropriate to undergo endoscopy and confirm the diagnosis. However, in low prevalence settings, as in primary health care centers, it would be of greater service to detect the presence of the disease.