June 2019. Volume 15. Number 2

The mumps vaccine is less immunogenic than that of measles, with no clear relation to the length of time past since vaccination

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Kennedy RB, Ovsyannikova IG, Thomas A, Larrabee BR, Rubin S, Poland GA. Differential durability of immune responses to measles and mumps following MMR vaccination. Vaccine. 2019;37:1775-84.

Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Complejo Asistencial Universitario de Palencia. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 25/05/2019
Acceptance date: 05/06/2019
Publication date: 12/06/2019

Abstract

Authors’s conclusions: the parotitis component of the MMR vaccine appears to be significantly less immunogenic than that of measles, with a higher decrease in antibody levels. There is a significant increase in the T cell response to mumps and measles, although for parotitis, this increase is small. The biological relevance of this difference is not clear.

Reviewer’s commentary: the small sample size and the origin of the cohort raise questions about the representativeness of the sample, although it is highly likely that in our environment a similar phenomenon occurs, since it is now a very common occurrence the diagnosis of adolescents with mumps. Revaccination should therefore be considered to improve protection, at least in the case of epidemic outbreaks.

How to cite this article

Ochoa Sangrador C, Andrés de Llano JM. La vacuna frente a la parotiditis es menos inmunógena que la de sarampión, sin relación clara con el tiempo desde la vacunación. Evid Pediatr. 2019;15:23.

AVC | Critically appraised articles

Kennedy RB, Ovsyannikova IG, Thomas A, Larrabee BR, Rubin S, Poland GA. Differential durability of immune responses to measles and mumps following MMR vaccination. Vaccine. 2019;37:1775-84.

Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Complejo Asistencial Universitario de Palencia. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 25/05/2019
Acceptance date: 05/06/2019
Publication date: 12/06/2019

How to cite this article

Ochoa Sangrador C, Andrés de Llano JM. La vacuna frente a la parotiditis es menos inmunógena que la de sarampión, sin relación clara con el tiempo desde la vacunación. Evid Pediatr. 2019;15:23.

12/06/2019

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